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Effects of Serum Lipid and Liver Tissue on Rats in Lectin from Viscum Album(Mistletoe)

겨우살이 Lectin이 흰쥐의 혈청지질 및 간조직에 미치는 영향

  • 장철수 (김천대학교 임상병리학과) ;
  • 류재기 (김천대학교 임상병리학과)
  • Received : 2012.04.03
  • Accepted : 2012.08.16
  • Published : 2012.09.28

Abstract

This study was carried out to investigate effect of serum lipid and liver tissue in lectin from Viscum album on rats. The lectin was purified by sepharose 4B affinity chromatography and gel filtration using sephadex G-150 with plant material from Viscum album. After 72 h of $CCl_4$ injection, there was a significant increase in serum total cholesterol and triglycerige levels relative to the control group. However, treatment of both Viscum album and purified lectin were significantly decreased lipid parameters against the $CCl_4$-induced. Histological observation of the liver section of rats challenged with $CCl_4$ produced a marked increase of cytoplasmic vacuoles in number, while rats administered olive oil alone did not alter the normal hepatic architecture. Histological observation of the liver section in rats treated 72 h with either Viscum album purified lectin or $CCl_4$-induced liver lipogenesis showed decreased numbers of cytoplasmic vaculoes and necrotic cells. These results suggest that Viscum album lectin has a significantly decreased lipid in serum or histological observation of the liver section decreased in lipogenesis in rats.

Keywords

Viscum Album;Lectin;Serum Lipid;Liver Tissue

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