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Effects of Ethanol Extracts from Zingiber officinale Rosc., Curcuma longa L., and Curcuma aromatica Salisb. on Acetylcholinesterase and Antioxidant Activities as well as GABA Contents

생강, 울금, 강황 추출물의 항산화 효과, AChE 억제활성 및 GABA 함량

  • Jung, Yeon-Seop (Dept. of Food Science and Technology, Keimyung University) ;
  • Park, Sung-Jin (Dept. of Food Science and Technology, Keimyung University) ;
  • Park, Jung-Hyun (The Center for Traditional Microorganism Resources, Keimyung University) ;
  • Jhee, Kwang-Hwan (Dept. of Applied Chemistry, Kumoh National Institute of Technology) ;
  • Lee, In-Seon (Dept. of Food Science and Technology, Keimyung University) ;
  • Yang, Seun-Ah (The Center for Traditional Microorganism Resources, Keimyung University)
  • 정연섭 (계명대학교 식품가공학과) ;
  • 박성진 (계명대학교 식품가공학과) ;
  • 박정현 (계명대학교 전통 미생물자원 개발 및 산업화 연구센터) ;
  • 지광환 (금오공과대학교 응용화학과) ;
  • 이인선 (계명대학교 식품가공학과) ;
  • 양선아 (계명대학교 전통 미생물자원 개발 및 산업화 연구센터)
  • Received : 2012.06.20
  • Accepted : 2012.09.24
  • Published : 2012.10.31

Abstract

This study investigated the cognition-related effects on antioxidant activities, ${\gamma}$-aminobutyric acid (GABA) contents, and AChE inhibitory activities in ethanol extracts from Zingiber officinale Rosc. (Korea), Curcuma longa L. (Korea), Curcuma longa L. (Myanmar), and Curcuma aromatica Salisb. (India). These extracts were investigated to determine the relationships among total polyphenols as well as DPPH and ABTS radical scavenging activities, GABA contents, and acetylcholinestrase (AChE) inhibitory activity. For the results, C. longa L. from Myanmar exhibited the highest contents of curcumin (97.1 ${\mu}g/mg$), total polyphenols (98.4 ${\mu}g/mg$), and GABA (1.31 ${\mu}g/mg$), as well as the strongest radical scavenging activities and AChE inhibitory activity. In addition, C. aromatica Salisb from India, which had the highest total polyphenol content (98.4 ${\mu}g/mg$) and strongest radical scavenging activities, exhibited relatively high AChE inhibitory activity similar to that of C. longa L. from Myanmar. On the other hand, Z. officinale Rosc. and C. longa L. from Korea showed low contents of curcumin (12.2 ${\mu}g/mg$) and polyphenols (85.7 ${\mu}g/mg$), as well as low AChE inhibitory activities. However, we could detect 1.11 ${\mu}g/mg$ of GABA in these extracts, which was similar to that of C. longa L. from Myanmar. Therefore, GABA content was not correlated with AChE inhibitory activity. Based on the results, AChE inhibitory activity is highly correlated with polyphenol contents in Zingibearceae family. Overall, among the Zingiberaceae tested, C. longa L. from Myanmar might be a strong candidate as a cognitive-enhancing ingredient.

Acknowledgement

Supported by : 한국연구재단, 지식경제부

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