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Anti-oxidative Effect of Oyster Hydrolysate on the Serum and Hepatic Homogenate in SD-rats

굴 가수분해물이 SD-Rat의 혈청과 간 균질물에 미치는 항산화 효과

  • Hur, Sung-Ik (Dept. of Seafood Science and Technology/Institute of Marine Industry, Gyeongsang National University) ;
  • Park, Si-Hyang (Sun Marine Biotech Co.) ;
  • Lee, Su-Seon (Sun Marine Biotech Co.) ;
  • Choung, Se Young (Dept. of Hygienic Chemistry, College of Pharmacy, Kyung Hee University) ;
  • Choi, Yeung Joon (Dept. of Seafood Science and Technology/Institute of Marine Industry, Gyeongsang National University)
  • 허성익 (경상대학교 해양식품공학과/해양산업연구소) ;
  • 박시향 (선마린바이오테크) ;
  • 이수선 (선마린바이오테크) ;
  • 정세영 (경희대학교 약학대학) ;
  • 최영준 (경상대학교 해양식품공학과/해양산업연구소)
  • Received : 2013.08.21
  • Accepted : 2013.11.27
  • Published : 2013.12.31

Abstract

This study is conducted to investigate the antioxidative effect of oyster hydrolysates in the serum and liver of SD-rats through the determination of lipid content, production of free radicals and antioxidant enzyme activities. Two different hydrolysates, Protamex-treated and Neutrase-treated hydrolysate with the cross-linking of protein by transglutaminase (TGPN group) and without (PN group), were fed for 6 weeks. TGPN hydrolysate in serum and liver significantly decreased the total cholesterol in the range of 26.1% to 28.9%, and triglyceride in the liver of up to 6.3%. Superoxide radical in the serum and lipid peroxide radical in the liver were significantly decreased in SD-rats fed 200 mg TGPN hydrolysate. Superoxide dismutase activity was significantly decreased in the liver of SD-rats. These results indicate that TGPN hydrolysate could scavenge the superoxide and hydroxyl radicals, and reduce the superoxide dismutase and catalase activities. The TGPN is also protected the oxidation of protein by the free radicals.

Acknowledgement

Supported by : 농림수산식품부

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