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The Improvement Effect of MMSC (DL-Methionine Methylsulfonium Chloride) in Functional Dyspepsia Animal Models

동물모델을 이용한 MMSC(DL-Methionine Methylsulfonium Chloride)의 기능성소화불량증 개선효과

  • Kim, Jae Min (National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorder, Inha Hospital) ;
  • Cha, Myoung Hee (National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorder, Inha Hospital) ;
  • Lee, Don Haeng (National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorder, Inha Hospital) ;
  • Lee, Woon Kyu (National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorder, Inha Hospital)
  • 김재민 (국가지정 소화기질환 의료제품 유효성평가 서비스센터) ;
  • 차명희 (국가지정 소화기질환 의료제품 유효성평가 서비스센터) ;
  • 이돈행 (국가지정 소화기질환 의료제품 유효성평가 서비스센터) ;
  • 이운규 (국가지정 소화기질환 의료제품 유효성평가 서비스센터)
  • Received : 2013.10.07
  • Accepted : 2013.10.15
  • Published : 2013.12.31

Abstract

The objective of this study is to investigate the gastric emptying and gastrointestinal transit improvement effect of DL-methionine methylsulfonium chloride (MMSC) in functional dyspepsia animal models. Cisplatin causes nausea, vomiting, and inhibition of gastric emptying. Rats were divided into four groups: G1 (normal group), G2 (gastric emptying induced by cisplatin), G3 (gastric emptying induced by cisplatin with itopride 30 mg/kg pretreatment), and G4 (gastric emptying induced by cisplatin with MMSC 4 mg/kg pretreatment). Immediately after an oral administration of a liquid meal (phenol red), delayed gastric emptying was induced by cisplatin (10 mg/kg (i.p.)). After 20 min in the cisplatin administration, the animals were sacrificed. In rats treated with cisplatin, the gastric emptying rate was significantly reduced. On the other hand, MMSC reversed the reduction of gastric emptying induced by cisplatin. And also, MMSC caused to travel FITC-dextran more significantly longer distance than the control, which is based on the values of the mean geometric center in the atropine driven delayed gastrointestinal transit animal models. Furthermore, MMSC drastically increased the gastrointestinal transit in rats, considerably increased the values of the mean geometric center (MGC), compared to the control, which was comparable to that of mosapride. These results suggest that MMSC could be an effective component for the treatment of functional dyspepsia.

Acknowledgement

Supported by : 한국보건산업진흥원

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