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Sleep-Induction Effects of GABA Coated Rice from Fermentation of Mono Sodium Glutamate

Mono Sodium Glutamate 발효로 얻은 GABA 코팅 쌀에 의한 수면유도 효과

  • Kim, Ok Ju (Department of Bioscience and Biotechnology, Graduate School, Silla University) ;
  • Lee, Jeong Kwang (Department of Pharmaceutical Engineering, College of Medical & Life Science, Silla University) ;
  • Woo, Young Min (Department of Pharmaceutical Engineering, College of Medical & Life Science, Silla University) ;
  • Choi, Seung Tae (Full & Fill Bio) ;
  • Park, Mi Yeon (Full & Fill Bio) ;
  • Kim, Andre (Department of Pharmaceutical Engineering, College of Medical & Life Science, Silla University) ;
  • Ha, Jong-Myung (Department of Bioscience and Biotechnology, Graduate School, Silla University)
  • Received : 2013.06.17
  • Accepted : 2013.08.29
  • Published : 2013.12.10

Abstract

Gamma-aminobutyric acid (GABA) is a non-protein amino acid widely present in organisms, which has shown several important physiological functions such as neurotransmission, hypotension induction, as well as diuretic and tranquilizer effects. They have also been extensively used in food industry. GABA contents in the grain and brown rice are about 1~4 mg/100 g and 4~8 mg/100 g, respectively but it is difficult to expect physiological activity from such low amounts of natural food intake. We investigate the effects of GABA-coated rice on the secretion of melatonin and serotonin which both have been used as sleep inductive compounds. As a result, the secretion of melatonin and serotonin from mice were found to be $3.578{\pm}0.158pg/mL$, $5.918{\pm}0.169ng/mL$ respectively. The melatonin and serotonin in mice increased significantly up to the 8.7 and 22.8 times respectively, when compared to that of the rice, but there was no cumulative effects. Due to the continuous intake of GABA-coated rice, which was developed as a functional food nutrient, inductive effects of melatonin and serotonin from general rice could be achieved and also the similar effect as taking up directly 25 mg/mL of GABA could be obtained.

Acknowledgement

Supported by : 농림수산식품부

References

  1. J. S. Chang, B. S. Lee, and Y. G. Kim, Changes in aaminobutyric aminobutyric acid (GABA) and the main constituents by a treatment conditions of anaerobically treated green tealeaves, Korean J. Food Sci. Technol., 24, 315-319 (1992).
  2. B. V. Manyam, L. Katz, T. A. Hare, K. Kaniefski, and R. D. Tremblay, Isoniazid-induced elevation of CSF GABA levels and effects on chorea in Huntington's disease, Ann. Neurol., 10, 35-37 (1981). https://doi.org/10.1002/ana.410100107
  3. W. B. Alan and J. S. Barry, The metabolism and functions of $\gamma$-aminobutyric acid, Plant Physiol., 115, 1-5 (1997). https://doi.org/10.1104/pp.115.1.1
  4. J. S. Barry, W. B. Alan, and D. M. Michael, Metabolism and function of gamma-aminobutyric acid, Trends in Plant Sci., 4, 446-452 (1999). https://doi.org/10.1016/S1360-1385(99)01486-7
  5. T. Tsukatani, T. Higuchi, and K. Matsumoto, Enzyme-based microtiter plate assay for $\gamma$-aminobutyric acid: Application to the screening of $\gamma$-aminobutyric acidproducing lactic acid bacteria, Anal Chim Acta., 540, 293-297 (2005). https://doi.org/10.1016/j.aca.2005.03.056
  6. I. Mody, Y. Dekoninck, T. S. Otis, and I. Soltesz, Bridging the cleft at GABA synapses in the brain, Trends Neurosci., 17, 517-528 (1994). https://doi.org/10.1016/0166-2236(94)90155-4
  7. A. G. Leventhal, Y. C. Wang, M. L. Pu, Y. F. Zhou, and Y. Ma, GABA and its agonists improved visual cortical function in senescent monkeys, Science, 300, 812-815 (2003). https://doi.org/10.1126/science.1082874
  8. W. Z. Potter, M. W. Fudirfer, and H. K. Manji, Potential New Pharmacotheraples for Refractory Depression, Int. Rev. Psychiatry., 9, 145-169 (1990).
  9. Y. S. Choi, J. H. Bahn, S. G. Jeon, Y. M. Chung, J. W. Hong, J. Y. Ahn, E. H. Lee, S. W. Cho, J. K. Park, and N. I. Beak, Stimulatory effect of ginsenosides on bovin brain glutamate decarboxylase, J. Biochem. Mol. Biol., 31, 233-239 (1998).
  10. S. H. Oh, Stimulation of $\gamma$-aminobutyric acid synthesis activity in brown rice by a chitosan/glutamic acid germination solution and calcium/calmodulin, J. Biochem. Mol. Biol., 36, 319-325 (2003). https://doi.org/10.5483/BMBRep.2003.36.3.319
  11. S. H. Oh and C. H. Oh, Brown rice extracts with enhanced levels of GABA stimulate immune cells, Food Sci. Biotechnol., 12, 248-252 (2003).
  12. S. H. Oh, Effects and applications of germinated brown rice with enhanced levels of GABA, Food Sic. Indus., 40, 41-46 (2007).
  13. Y. R. Cho, Y. J. Chang, and H. C. Chang, Production of $\gamma$-aminobutyric acid (GABA) by Lactobacillus buchneri isolated from kimchi and its neuroprotective effect on neuronal cells. J. Microviol. Biotechnol., 17, 104-109 (2007).
  14. M. L. Cross, Immune-signaling by orally-delivered probiotic bacteria: Effects on common mucosal immunoresponses and protection at distal mucosal sites, Int. J. Immunopathol. Pharmacol., 17, 127-134 (2004). https://doi.org/10.1177/039463200401700204
  15. S. B. Han and Y. H. Kim, Production method of $\gamma$-aminobutyric acid-enforced fermentative products by lactic acid bacteria, $\gamma$-aminobutyric acid-enforced fermentative products producedby the method and their utilization. Korea Patent, 10-0547018 (2006).
  16. J. H. Jeun, H. D. Kim, H. S. Lee, and B. H. Ryu, Kor. Isolation and identification of Lactobacillus sp. produced $\gamma$-aminobutyric acid (GABA) form traditional slat fermented anchovy, J. Food. Nutr., 1, 72-79 (2004).
  17. G. Muramoto and S. Kawamura, Rice protein and antihypertensive peptide from rice, Nippon Shokuhin Kougyo., 34, 18-26 (1991).
  18. K. Y. Park, C. S. Kang, Y. C. Cho, Y. S. Lee, Y. H. Lee, and Y. S. Lee, Genotypic difference in tocotrienol contents of rice bran, Korean J. Crop. Sci., 48, 469-472 (2003).
  19. S. R. Kim, J. Y. Ahn, H. Y. Lee, and T. Y. Ha, Various properties and phenolic acid contents of rices and rice brans with different milling fractions, Korean J. Food Sci. Technol., 36, 930-936 (2004).
  20. S. K. Oh, D. J. Kim, A. R. Chun, M. R. Yoon, K. J. Kim, J. S. Lee, H. C. Hong, and Y. K. Kim, Antioxidant compounds and antioxidant activities of ethanol extracts from milling by-products of rice cultivars, J. Korean Soc. Food Sci. Nutr., 39, 624-630 (2010). https://doi.org/10.3746/jkfn.2010.39.4.624
  21. J. Axelord and H. Weissbach, Enzymatic O-methylation of N-acetylserotonin to melatonin, Science, 131, 1312-1312 (1960). https://doi.org/10.1126/science.131.3409.1312
  22. A. B. Lerner and J. D. Case, Melatonin, Fed Proc., 19, 590-592 (1960).
  23. Illnerova H, The Suprachiasmatic nucleus and rhythmic pineal melatonin production, Suprachiasmatic nucleus: the mind's clock, 197, Oxford University Press, New York (1991).
  24. C. H. Oh and S. H. Oh, Effects of germinated brown rice extracts with enhanced levels of GABAon cancer cell proliferation and apotosis, J. Med. Food., 7, 19-23 (2004). https://doi.org/10.1089/109662004322984653
  25. S. S. Kim, S. H. Oh, M. H. Jeong, S. C. Cho, M. C. Kook, S. H. Lee, Y. R. Pyun, and H. Y. Lee, Sleep-Inductive Effect of GABA on the Fermentation of Mono Sodium Glutamate (MSG), Korean J. Food Sci. Technol., 42, 142-146 (2010).
  26. S. Y. Kang, K. Y. Lee, M. J. Park, Y. C. Kim, G. J. Maekelonis, T. H. Oh, and Y. C. Kim, Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice, Neurobiol. Learn. Mem., 79, 11-18 (2003). https://doi.org/10.1016/S1074-7427(02)00007-2
  27. C. A. Czeisler, Suppression of Melatonin Secretion in Some Blind Patients by Exposure to Bright Light, N. Engl. Med. J. Med., 332, 6-11 (1995). https://doi.org/10.1056/NEJM199501053320102
  28. Y. Y. Hong, I. S. Moon, D. I. Kim, and T. K. Lee, A study on melatonin, serotonin secretion change and behavior in the rats treated with Yiseontang, Gammakdaejotang, Sanjointang, and Sanjogammaktang, J. Orient. Gynecol., 12, 209-230 (1999).

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