A Study on Concentrations of Heavy Metal in Blood and Urine of Local Area in Korea

국내 일부 지역주민의 혈액과 요중 중금속 농도에 관한 연구

  • Received : 2012.08.24
  • Accepted : 2013.01.10
  • Published : 2013.01.31


The purpose of this study is to assess the effects of heavy metal concentrations in the blood and urine of the general population. This research had been conducted from April to December 2008, studying 545 residents of Daejeon and Chungcheong Province. Through the concentrations of heavy metals(Pb, Cd, Hg, As, Mn) in the biota samples and questionnaires, the residents heavy metal exposure level and the influential factors according to personal characteristics or lifestyle were evaluated. As to the heavy metal concentration in the blood and urine of the comparing region, were As and Mn statistically significant(p<0.01, p<0.05). Blood lead and urinary mercury concentrations were higher in males than females. The heavy metal concentration for each age group increased blood mercury. The concentration of all heavy metals were higher in the drinkers than in the non-drinkers. Blood lead and mercury concentrations were higher in the smokers than in the non-smokers, but the urinary cadmium, arsenic and blood manganese was higher in the non-smokers than in the smokers. As to the blood lead and urinary cadmium concentration according to the food preference fish showed high concentration. To clarify the factors affecting the heavy metal concentration in biota among subjects multiple regression analysis was conducted. As a results, it turned out that as to lead content in blood, sex, age and smoking have influence on the subjects with explanatory adequacy of 14.0 %. These results demonstrated that the factors affected the concentrations of heavy metals in blood and urine. The results of this study could be used as the foundational data for setting the health risk assessment.


Heavy metals;Urine;Blood;Residents


  1. Abernathy, C. O., Thomas, D. J., Calderon, R. L., 2003, Health effects and risk assessment of arsenic, J. Nutr., 133, 1536-1538.
  2. Ahn, S. C., 2005, Factors influencing urinary mercury concentration in schoolchildren, M. Dissertation, Yeonse University, Seoul, Korea.
  3. Bae, H. S., 2012, Urinary arsenic concentration in korean adults and related factors, M. Dissertation, Chungang University, Seoul, Korea.
  4. Bernhard, D., Rossmann, A., Wick, G., 2005, Metals in cigarette smoke, IUBMB Life., 57(12), 805-809.
  5. Briganti, E. M., Branley, P., Chadban S. J., Shaw, J. E., McNeil, J. J., Welborn, T. A., Atkins, R. C., 2002, Smoking is associated with renal impairment and proteinuria in the normal population: the ausdiab kidney study, austalian diabetes, obesity and lifestyle study, J. Kidney Dis., 40(4), 704-712.
  6. Choi, B. S., Choi, S. J., Kim, D. W., Huang, M., Kim, N. Y., Park, K. S., Kim, C. Y., Lee, H. M., Yum, Y. N., Han, E. S., Kang, T. S., Yu, I. J., Park, J. D., 2010, Effects of repeated seafood consumption on urinary excretion of arsenic species by volunteers, Arch Environ Contam Toxicol., 58(1), 222 - 229.
  7. Choi, C. I., Kim, J. H., 2006, An inaternational comparative study on the relationship between economic growth and environmental pollution : testing the existence of EKC in $CO_{2}$, J. KPA., 41(1), 153-166.
  8. Goyert, R., 2001, Toxic effects of metals, In : Klassen CD. Casarett & Doull's Toxicology : The basic science of poison. 6th ed., Megraw-Hill companies Inc., 822-1286.
  9. Ho, M. K., 2003, A Study on the association between factor of health/life and blood mercury concentration, M. Dissertation, Yeonse University, Seoul, Korea.
  10. Hsueh, Y. M., Hsu, M. K., Chiou, H. Y., Yang, M. H., Huang, C. C., Chen, C. J., 2002, Urinary arsenic speciation in subjects with or without restriction from seafood dietary intake, J. Toxicol Lett., 33(1), 83 - 91.
  11. Im, J. E., Kang, E. Y., Choi, B. S., Seo, J. Y., Hong, Y. P., Jang, I. W., Park, J. D., 2000, The distribution of blood lead concentration by age and sex in growing students, J. Chung-Ang Med., 25(2), 87-91.
  12. Jang, B. K., Park, S. I., Kim, N. S., Jung, K. S., Lee, B. K., Lee, J. H., 2011, Relationship between heavy metal concentrations in the soil with the blood and urine of residents around abandoned metal mines, J. Environ Health Sci., 37(5), 348-357.
  13. Jeon, J. M., Hur, D., Kim, D. S., 2003, Trend of volitile organic compounds in the ambient air of yeosu industrial complex, J. KOSAE., 9(6), 663-677.
  14. Jo, H. M., 2008, Heavy metal levels in blood and urine of residents in industrial area, M. Dissertation, Soonchunhayang University, Asan, Korea.
  15. Jung, Y. R., 2007, Comparative study of nutrients intake status and blood Cd, Pb levels and bone mineral density between Korean non-smoking and smoking male college students, M. Dissertation, Sookmyung University, Seoul, Korea.
  16. Kim, C. W., Kim, Y. W., Chae, C. H., Son, J. S., Park, S. H., Ko, J. C., Kim, D. S., 2010, The effects of the frequency of fish consumption on the blood mercury levels in koreans, J. Occup Environ Med., 22(2), 114-121.
  17. Kim, H. O., 1993, The Effect of dietary iron levels on the metabolism of iron, zinc, lead and serum lipids in lead poisoned rats, M. Dissertation, Sookmyung University, Seoul, Korea.
  18. Kim, H. J., Hong, Y. S., Lee, K. E., Kim, D. S., Lee, M. J., Yeah, B. J., Yoo, C. I., Kim, Y. O., Yoo, B.C., Kim, Y. H., Kim, J. M., Kim, J. Y., 2009, The levels of blood lead and cadmium in urban and rural population in Korea, J. Life Science., 19(4), 472-478.
  19. Kim, J. M., Ahn, J. M., Kim, W. S., Kim, J. I., Shin, H. R., Jung, K. Y., Kim, J. Y., 2000, Blood lead, manganese, aluminium and silicon concentrations in korean Adults, J. Prev Med., 33(2), 157 - 164.
  20. Kim, N. Y., 2008, Effects of life-style on the blood mercury levels in Korean, M. Dissertation, Chungang University, Seoul, Korea.
  21. Kim, Y. H., 2009, Health effects of manganese and some recent issues in manganese neurotoxicity research, J. KSEM., 21(1), 87-105.
  22. Lee, B. R., Ha, J. H., 2011, The effects of smoking and drinking on blood lead and cadmium levels: data from the fourth korea national health and nutrition examination survey, J. Occup Environ Med., 23(1), 31-41.
  23. Lee, J. E., 2011, Blood lead level nutrition characteristics in Korean, M. Dissertation, Inje University, Kimhae, Korea.
  24. Lee, M. J., Moon, D. H., Cho, Y. H., Lee, J. T., Han, Y. S., Jung, G. O., 1995, Heavy metal concentration in serum of rural inhabitants, J. Inje Med., 16(2), 311-325.
  25. Lewis, R., 2007, Metals in: ladou J(eds) current occupational & environmental medicine, 4th ed., McGraw-Hill Co., New York, 418-423.
  26. Lee, S. J., 2010, A study on the levels of heavy metal in blood and urine of some residents in the Ulsan area, M. Dissertation, Hanyang University, Seoul, Korea.
  27. Liou, S. H., Wu, T. N., Chiang, H. C., Yang, T., Yang, G. Y., Wu, Y. Q., Lai, J. S., Ho, S. T., Guo, Y. L., Ko, Y. C., Ko, K. N., Chang, P. Y., 1996, Threeyear survey of blood lead levels in 8828 Taiwanese adults, Int Arch Occup Environ Health., 68, 80-87.
  28. Liao, X. Y., Chen, T. B., Xie, H., Liu, Y. R., 2005, Soil As contamination and its risk assessment in areas near the industrial districts of Chenzhou city, Southern China, Environ Int., 31(6), 791-798.
  29. Mead, M. N., 2005, Arsenic: in search of an antidote to a global poison, Environ Health Perspect., 113, 378-386.
  30. Milton, A. H., Rahman, M., 2002, Respiratory effects and arsenic contaminated well water in Bangladesh, J. Environ Health Res., 12(2), 175-179.
  31. Min, K. B., 2002, Effect of environmental factors on blood lead levels, M. Dissertation, Seoul University, Seoul, Korea.
  32. Moon, D. H., Song, I. H., 1999, A Study on heavy metals concentration in urine of healthy females living in four cities, J. Inje Med., 20(1), 385-394.
  33. Nam, H. S., Won, Y. J., Seo, I. W., Yoon, C. Y., Lee, D. M., Park, D. H., Lee, H. M., Kim, S. S., Kim, H. J., Lee, K. Y., 2002, Study on hazarous metal contents of circulating vegetables in Korea, Annu. Rep. KFDA., 6, 162-168.
  34. National Institute of Environmental Research., 1997, Estimating the reference value of heavy metals in blood and urine among the residential area populations, 97-01-492.
  35. National Institute of Environmental Research, 2008, Hazardous materials survey of the third national bioanalytical.
  36. Noo, S. J., 2007, Effects of smoking on heavy metal contents in blood and health status of undergraduate. M. Dissertation, Soonchunhyang University, Asan, Korea.
  37. Park, J. M., Lee, S. B., Cha, J. S., Kwon, O. S., Lee, S. H., 2008, Characteristics of heavy metal emissions from stationary sources, J. KOSAE., 24(5), 574-583.
  38. Sartor, F. A., Rondia, D. J., Claeys, F. D., Staessen, J. A., Lauwerys, R. R., Bernard, A. M., Buchet, J. P., Roels, H. A., Bruaux, P. J., Ducoffre, G. M., 1992, Impact of environmental cadmium pollution on cadmium exposure and body burden, Arch Environ Health, 47(5), 347-53.
  39. Son, D. J., Choi, E. M., Seo, Y. S., Lee, S. M., 2008, Characterization of blood mercury levels in adults in Korea, Proceeding of the 47th Meeting of Korean Soc Atomospheric Environ, 417-418.
  40. Tsukahara, T., Ezaki, T., Moriguchi, J., Furuki, K., Fukui, Y., Ukai, H., Okamoto, S., Sakurai, H., Ikeda, M., 2003, No significant effect of iron deficiency on cadmium body burden or kidney dysfunction among women in the general population in Japan. Int Arch Occup Environ Health, 76(4), 275-281.
  41. Yoon, C. K., 1991, A Study on the blood level of heavy metals in industrial workers, Ph. D. Dissertation, Chungnam University, Daejeon, Korea.

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