A System for Concurrent TMS-fMRI and Evaluation of Imaging Effects

동시 뇌경두개자기자극-기능자기공명영상 시행을 위한 홀더 제작과 시뮬레이션 및 영상 데이터 평가

  • Kim, Jae-Chang (Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine) ;
  • Kyeong, Sunghyon (Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine) ;
  • Lee, Jong Doo (Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine) ;
  • Park, Hae-Jeong (Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine)
  • 김재창 (연세대학교 의과대학 BK21 연세의과학사업단) ;
  • 경성현 (연세대학교 의과대학 BK21 연세의과학사업단) ;
  • 이종두 (연세대학교 의과대학 BK21 연세의과학사업단) ;
  • 박해정 (연세대학교 의과대학 BK21 연세의과학사업단)
  • Received : 2013.06.13
  • Accepted : 2013.06.20
  • Published : 2013.09.30


Purpose : The purpose of this study was to setup a concuurent transcranial magnetic stimulation (TMS)-functional MRI (fMRI) system for understanding causality of the functional brain network. Materials and Methods: We manufactured a TMS coil holder using nonmagnetic polyether ether ketone (PEEK). We simulated magnetic field distributions in the MR scanner according to TMS coil positions and angles. To minimize image distortions caused by TMS application, we controlled fMRI acquisition and TMS sequences to trigger TMS during inter-volume intervals. Results: Simulation showed that the magnetic field below the center of the coil was dramatically decreased with distance. Through the MR phantom study, we confirmed that TMS application around inter-volume acquisition time = 100 miliseconds reduced imaging distortion. Finally, the applicability of the concurrent TMS-fMRI was tested in preliminary studies with a healthy subject conducting a motor task within TMS-fMRI and passive motor movement induced by TMS in fMRI. Conclusion: In this study, we confirmed that the developed system allows use of TMS inside an fMRI system, which would contribute to the research of brain activation changes and causality in brain connectivity.


Supported by : 한국연구재단


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