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Near-field Evaluation of Surface Plasmon Resonance Biosensor Sensitivity Based on the Overlap Between Field and Target Distribution

근접장-분자반응 간의 중첩을 이용한 표면 플라스몬 공명 센서 감도 평가에 관한 연구

  • Ryu, Yeonsoo (School of Electrical and Electronic Engineering, Yonsei Institute of Medical Instruments Technology, Yonsei University) ;
  • Son, Taehwang (School of Electrical and Electronic Engineering, Yonsei Institute of Medical Instruments Technology, Yonsei University) ;
  • Kim, Donghyun (School of Electrical and Electronic Engineering, Yonsei Institute of Medical Instruments Technology, Yonsei University)
  • 류연수 (연세대학교 전기전자공학부, 의료기기기술 연구소) ;
  • 손태황 (연세대학교 전기전자공학부, 의료기기기술 연구소) ;
  • 김동현 (연세대학교 전기전자공학부, 의료기기기술 연구소)
  • Received : 2013.03.18
  • Accepted : 2013.04.05
  • Published : 2013.04.25

Abstract

In this study, we have investigated the correlation of far-field detection sensitivity of surface plasmon resonance (SPR) biosensors with optical signatures associated with the near-field overlap of biomolecules. The results confirm a direct relation between the far-field and near-field parameters, particularly for optical signatures defined in terms of lateral electric field components that are tangential to the interface and thus continuous across the interface. The overall correlation between near-field optical signatures and far-field resonance shift exceeded 97%. The results can be highly useful to evaluate detection sensitivity of SPR biosensors that take advantage of complex structures for localization of surface waves.

Acknowledgement

Supported by : 한국연구재단

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