Anti-nociceptive Activity of Methanol Extracts from Ligularia stenocephala

곤달비 메탄올 추출물의 진통 효과

  • 차동석 (우석대학교 약학대학) ;
  • 전훈 (우석대학교 약학대학)
  • Received : 2013.03.04
  • Accepted : 2013.03.12
  • Published : 2013.03.31


Ligularia stenocephala has been widely used as a traditional medicine for the treatment of lots of diseases such as asthma, arthritis, and jaundice. In this study, we evaluated the anti-nocicepitve activities of methanolic extract of L. stenocephala (MLS) using various pain models including thermal nociception as well as chemical nociception methods. MLS showed significant increase in latency time in the tail immersion test and hot-plate test. In addition, the number of acetic acid-induced abdominal constrictions was decreased by MLS. MLS also attenuated paw licking time in the formalin test. The combination test using naloxone revealed that the anti-nociceptive properties of MLS was not associated with opioid receptor activation. The present results demonstrate that MLS may possibly used as valuable analgesic agent for the treatment of nociceptive pain.


Supported by : 우석대학교


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