Molecular Mechanism of Inflammatory Signaling and Predominant Role of Saposhnikovia divaricata as Anti-inflammatory Potential

  • Khan, Salman (Natural Product Research Institute, College of Pharmacy, Seoul National University) ;
  • Kim, Yeong Shik (Natural Product Research Institute, College of Pharmacy, Seoul National University)
  • Received : 2013.06.06
  • Accepted : 2013.06.20
  • Published : 2013.06.30

Abstract

Natural products have always been a pivotal source of new drug development. Dry roots of Saposhnikovia divaricata (Turcz.) Schischk. (Umbelliferae) is a perennial herb and is also known as Bang Pung in traditional medicine. Numerous in vitro and in vivo studies have revealed the diverse pharmacological effects of S. divaricata and its role in the treatment of various diseases. This herb has exhibited significant inhibitory effects against inflammation and associated disorders. The present study explored the ethnopharmacological applications and molecular mechanisms behind the anti-inflammatory effects of S. divaricata herb and a single compound blockade of multi-signaling inflammatory cascades. Taken together, this review provides insight into the potential role of S. divaricata against various inflammatory diseases.

References

  1. Aderem, A. and Ulevitch, R.J., Toll-like receptors in the induction of the innate immune response. Nature 406, 782-787 (2000). https://doi.org/10.1038/35021228
  2. Bartleson, J.D. and Cutrer, F.M., Migraine update. Diagnosis and treatment. Minn Med. 93, 36-41 (2010).
  3. Brazil, D.P. and Hemmings, B.A., Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci. 26, 657-664 (2001). https://doi.org/10.1016/S0968-0004(01)01958-2
  4. Cao, T.T., Ma, L., Kandpal, G., Warren, L., Hess, J.F., and Seabrook, G.R., Increased nuclear factor-erythroid 2 p45-related factor 2 activity protects SH-SY5Y cells against oxidative damage. J Neurochem. 95, 406-417 (2005). https://doi.org/10.1111/j.1471-4159.2005.03377.x
  5. Coussens, L.M. and Werb, Z., Inflammation and cancer. Nature 420, 860-867 (2002). https://doi.org/10.1038/nature01322
  6. Covert, M.W., Leung, T.H., Gaston, J.E., and Baltimore, D., Achieving stability of lipopolysaccharide-induced NF-${\kappa}B$ activation. Science 309, 1854-1857 (2005). https://doi.org/10.1126/science.1112304
  7. Dinarello, C.A., Anti-inflammatory Agents: Present and Future. Cell 140, 935-950 (2010). https://doi.org/10.1016/j.cell.2010.02.043
  8. Dinh, P., Hazel, A., Palispis, W., Suryadevara, S., and Gupta, R., Functional assessment after sciatic nerve injury in a rat model. Microsurgery 29, 644-649 (2009). https://doi.org/10.1002/micr.20685
  9. Gaestel, M., Kotlyarov, A., and Kracht, M., Targeting innate immunity protein kinase signalling in inflammation. Nat Rev Drug Discov. 8, 480-499 (2009). https://doi.org/10.1038/nrd2829
  10. Ge, W.H., Guo, J.Y., Shen, Y.J., Chen, M.L., Shi, S.L., Han, Y.H., and Lin, J., Effects of volatie oil of Schizonepeta tenuifolia Briq herb and Saposhnikovia divaricata Schischke root on proinflammatory cytokine expression and regulation. Zhongguo Zhong Yao Za Zhi. 32, 1777-1779 (2007).
  11. Gilroy, D.W., Lawrence, T., Perretti, M., and Rossi, A.G., Inflammatory resolution: new opportunities for drug discovery. Nat Rev Drug Discov. 3, 401-416 (2004). https://doi.org/10.1038/nrd1383
  12. Glass, C.K., Saijo, K., Winner, B., Marchetto, M.C., and Gage, F.H., Mechanisms underlying inflammation in neurodegeneration. Cell 140, 918-934 (2010). https://doi.org/10.1016/j.cell.2010.02.016
  13. Guo, W., Sun, J., Jiang, L., Duan, L., Huo, M., Chen, N., Zhong, W., Wassy, L., Yang, Z., and Feng, H., Imperatorin attenuates LPSinduced inflammation by suppressing NF-${\kappa}B$ and MAPKs activation in RAW 264.7 macrophages. Inflammation 35, 1764-1772 (2012). https://doi.org/10.1007/s10753-012-9495-9
  14. Hampe, J., Grebe, J., Nikolaus, S., Solberg, C., Croucher, P.J., Mascheretti, S., Jahnsen, J., Moum, B., Klump, B., Krawczak, M., Mirza, M.M., Foelsch, U.R., Vatn, M., and Schreiber, S., Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study. Lancet 359, 1661-1662 (2002). https://doi.org/10.1016/S0140-6736(02)08590-2
  15. Harvey, A.L., Natural products in drug discovery. Drug Discov Today 13, 894-901 (2008). https://doi.org/10.1016/j.drudis.2008.07.004
  16. Hata, K., Kozawa, M., Ikeshiro, Y., and Yen, K.Y., New coumarins isolated from the root of Peucedanum formosanum Hayata and Peucedanum japonicum Thunb. Yakugaku Zasshi 88, 513-520 (1968).
  17. Hattori, Y., Hattori, S., and Kasai, K., Lipopolysaccharide activates Akt in vascular smooth muscle cells resulting in induction of inducible nitric oxide synthase through nuclear factor-${\kappa}B$ activation. Eur J Pharmacol. 481, 153-158 (2003). https://doi.org/10.1016/j.ejphar.2003.09.034
  18. Hayden, M.S. and Ghosh, S., Signaling to NF-${\kappa}B$. Genes Dev. 18, 2195-224 (2004). https://doi.org/10.1101/gad.1228704
  19. Hsiao, G., Ko, F.N., Jong, T.T., and Teng, C.M., Antiplatelet action of 3',4'-diisovalerylkhellactone diester purified from Peucedanum japonicum Thunb. Biol Pharm Bull. 21, 688-692 (1998). https://doi.org/10.1248/bpb.21.688
  20. Inohara, N., Ogura, Y., Chen, F.F., Muto, A., and Nunez, G., Human Nod1 confers responsiveness to bacterial lipopolysaccharides. J Biol Chem. 276, 2551-2554 (2001). https://doi.org/10.1074/jbc.M009728200
  21. Inohara, N., Ogura, Y., and Nunez, G., Nods: a family of cytosolic proteins that regulate the host response to pathogens. Curr Opin Microbiol. 5, 76-80 (2002). https://doi.org/10.1016/S1369-5274(02)00289-8
  22. Khan, S., Shin, E.M., Choi, R.J., Jung, Y.H., Kim, J., Tosun, A., and Kim, Y.S., Suppression of LPS-induced inflammatory and NF-${\kappa}B$ responses by anomalin in RAW 264.7 macrophages. J Cell Biochem. 112, 2179-2188 (2011). https://doi.org/10.1002/jcb.23137
  23. Kim, T.H., Yoon, S.J., Lee, W.C., Kim, J.K., Shin, J., Lee, S., and Lee, S.M., Protective effect of GCSB-5, an herbal preparation, against peripheral nerve injury in rats. J Ethnopharmacol. 136, 297-304 (2011). https://doi.org/10.1016/j.jep.2011.04.037
  24. Kuo, Y.C., Lin, Y.L., Huang, C.P., Shu, J.W., and Tsai, W.J., A tumor cell growth inhibitor from Saposhnikovae divaricata. Cancer Invest. 20, 955-964 (2002). https://doi.org/10.1081/CNV-120005911
  25. Li, G.Q., Zhang, Y.B., and Guan, H.S., A new isoxazol from Glehnia littoralis. Fitoterapia 79, 238-239 (2008). https://doi.org/10.1016/j.fitote.2008.01.002
  26. Malagelada, J.R., A symptom-based approach to making a positive diagnosis of irritable bowel syndrome with constipation. Int J Clin Pract. 60, 57-63 (2006).
  27. Mantovani, A., Allavena, P., Sica, A., and Balkwill, F., Cancer-related inflammation. Nature 454, 436-444 (2008). https://doi.org/10.1038/nature07205
  28. Nathan, C., Points of control in inflammation. Nature 420, 846-52 (2002). https://doi.org/10.1038/nature01320
  29. Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K., and Kimoto, M., MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med. 189, 1777-1782 (1999). https://doi.org/10.1084/jem.189.11.1777
  30. Sies, H., Oxidative stress: oxidants and antioxidants. Exp Physiol. 82, 291-295 (1997).
  31. Tai, J. and Cheung, S., Anti-proliferative and antioxidant activities of Saposhnikovia divaricata. Oncol Rep. 18, 227-234 (2007).
  32. Tergaonkar, V., NF-${\kappa}B$ pathway: a good signaling paradigm and therapeutic target. Int J Biochem Cell Biol. 38, 1647-1653 (2006). https://doi.org/10.1016/j.biocel.2006.03.023
  33. Thimmulappa, R.K., Lee, H., Rangasamy, T., Reddy, S.P., Yamamoto, M., Kensler, T.W., and Biswal, S., Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest. 116, 984-995 (2006). https://doi.org/10.1172/JCI25790
  34. Thomas, K.W., Monick, M.M., Staber, J.M., Yarovinsky, T., Carter, A.B., and Hunninghake, G.W., Respiratory syncytial virus inhibits apoptosis and induces NF-${\kappa}B$ activity through a phosphatidylinositol 3-kinasedependent pathway. J Biol Chem. 277, 492-501 (2002).
  35. Vezzani, A., French, J., Bartfai, T., and Baram, T.Z., The role of inflammation in epilepsy. Nat Rev Neurol. 7, 31-40 (2011). https://doi.org/10.1038/nrneurol.2010.178
  36. Wang, C.C., Chen, L.G., and Yang, L.L., Inducible nitric oxide synthase inhibitor of the Chinese herb I. Saposhnikovia divaricata (Turcz.) Schischk. Cancer Lett. 145, 151-157 (1999). https://doi.org/10.1016/S0304-3835(99)00248-7
  37. Wang, F.R., Xu, Q.P., and Li, P., 1991. Comparative studies on the febrifugal analgesic and anticonvulsive activities of water extracts from cultivated and wild Saposhnikovia divaricata. Zhong Xi Yi Jie He Za Zhi. 11, 730-732, 710 (1991).
  38. Wellen, K.E. and Hotamisligil, G.S., Inflammation, stress, and diabetes. J Clin Invest. 115, 1111-1119 (2005). https://doi.org/10.1172/JCI200525102
  39. Wollina, U. and Verma, S.B., Rosacea and rhinophyma: not curse of the Celts but Indo Eurasians. J Cosmet Dermatol. 8, 234-235 (2009). https://doi.org/10.1111/j.1473-2165.2009.00456.x
  40. Yoon, T., Cheon, M.S., Lee, A.Y., Lee do, Y., Moon, B.C., Chun, J.M., Choo, B.K., and Kim, H.K., Anti-inflammatory activity of methylene chloride fraction from Glehnia littoralis extract via suppression of NF-${\kappa}B$ and mitogen-activated protein kinase activity. J Pharmacol Sci. 112, 46-55 (2010). https://doi.org/10.1254/jphs.09168FP
  41. Zhang, Z., Oliver, P., Lancaster, J.R., Jr., Schwarzenberger, P.O., Joshi, M.S., Cork, J., and Kolls, J.K., Reactive oxygen species mediate tumor necrosis factor ${\alpha}$-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate. FASEB J. 15, 303-305 (2001).
  42. Zhang, Z.Q., Tian, Y.J., and Zhang, J., Studies on the antioxidative activity of polysaccharides from radix Saposhnikoviae. Zhong Yao Cai. 31, 268-272 (2008).
  43. Zhao, B., Yang, X.B., Yang, X.W., and Liu, J.X., Biotransformation of prim-O-glucosylcimifugin by human intestinal flora and its inhibition on NO production and DPPH free radical. J Asian Nat Prod Res. 14, 886-896 (2012). https://doi.org/10.1080/10286020.2012.702756
  44. Hotamisligil, G.S., Inflammation and metabolic disorders. Nature 444, 860-867 (2006). https://doi.org/10.1038/nature05485
  45. Okuyama, E., Hasegawa, T., Matsushita, T., Fujimoto, H., Ishibashi, M., and Yamazaki, M., Analgesic components of saposhnikovia root (Saposhnikovia divaricata). Chem Pharm Bull (Tokyo). 49, 154-160 (2001). https://doi.org/10.1248/cpb.49.154