Anti-nociceptive Activity of Acer tegmentosum MeOH Extract

산청목 메탄올 추출물의 진통 효과

  • 서현원 (우석대학교 약학대학) ;
  • 박경재 (우석대학교 약학대학) ;
  • 곽귀희 (우석대학교 약학대학) ;
  • 임준상 (우석대학교 약학대학) ;
  • 김대근 (우석대학교 약학대학) ;
  • 임재윤 (우석대학교 약학대학) ;
  • 차동석 (우석대학교 약학대학) ;
  • 권진 (한국복지대학 의료보장구과) ;
  • 오찬호 (우석대학교 식품생명공학과) ;
  • 전훈 (우석대학교 약학대학)
  • Received : 2013.05.03
  • Accepted : 2013.06.10
  • Published : 2013.06.30

Abstract

Acer tegmentosum which is belongs to Aceraceae has been widely used as a traditional medicine for the treatment of lots of diseases including pain management. In this study, we evaluated the anti-nocicepitve effects of methanolic extract of A. tegmentosum (MAT) in mice using various pain models. MAT presented strong and dose-dependent anti-nociceptive activities on thermal nociception models such as tail-immersion test and hot plate test. Moreover, acetic acid-induced chemical nociception was signigicantly reduced by MAT treatment. We could confirm MAT's central and peripheral analgesic properties by formalin test. We also found that the pre-treatment of opioid receptor antagonist did not alter the MAT's anti-nociception, suggesting opioid receptor is not involved in analgesic activity of MAT. Based on our results, we could conclude that MAT may be possibly used as an anti-nociceptive agent for the treatment of various nociceptive pains.

Acknowledgement

Supported by : 우석대학교

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