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Acetylation of Retinoblastoma Like Protein2 (Rb2/p130) in Tumor Tissues

  • Khan, Z.N. (Department of Biosciences, COMSATS Institute of Information Technology (CIIT)) ;
  • Sabir, M. (Department of Biosciences, COMSATS Institute of Information Technology (CIIT)) ;
  • Kayani, M.A. (Department of Biosciences, COMSATS Institute of Information Technology (CIIT)) ;
  • Saeed, M. (Department of Biosciences, COMSATS Institute of Information Technology (CIIT))
  • Published : 2013.04.30

Abstract

The activity of Rb proteins is controlled by post-translational modifications, especially through phosphorylation. Acetylation of Rb2/p130 was reported recently in NIH3T3 cells but its physiological relevance in cell cycle control and tumorigenesis is still unknown. Efforts are underway to investigate possible interplay between Rb2/p130 phosphorylation and acetylation. Here we hypothesized that Rb2/p130 acetylation, like p53 acetylation, may play a role in development of the tumor phenotype. The proposed hypothesis regarding acetylation of Rb2/p130 in tumor VS normal cells was found to be true in our case study of 36 tumor samples. Statistical analysis of results suggest strong correlation among Rb2/p130 acetylation and cancer phenotype.

Acknowledgement

Supported by : Higher Education Commission

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