Chemical burns of the oral mucosa caused by Policresulen: report of a case

Policresulen 오용에 의한 구강 궤양의 발병 증례 및 화학화상에 대한 고찰

  • Jung, Jung-Woo (Department of Oral Medicine, School of Dentistry, Kyungpook National University) ;
  • Byun, Jin-Seok (Department of Oral Medicine, School of Dentistry, Kyungpook National University) ;
  • Jung, Jae-Kwang (Department of Oral Medicine, School of Dentistry, Kyungpook National University) ;
  • Choi, Jae-Kap (Department of Oral Medicine, School of Dentistry, Kyungpook National University)
  • 정정우 (경북대학교 치의학전문대학원 구강내과학교실) ;
  • 변진석 (경북대학교 치의학전문대학원 구강내과학교실) ;
  • 정재광 (경북대학교 치의학전문대학원 구강내과학교실) ;
  • 최재갑 (경북대학교 치의학전문대학원 구강내과학교실)
  • Received : 2013.05.11
  • Accepted : 2013.05.31
  • Published : 2013.06.30


Chemical burn on the oral mucosa is caused by contact with various chemical products and manifests with localized mucositis, keratotic white lesions, bleeding, and painful tissue surface due to the coagulation of the tissue. Policresulen ($Albothyl^{(R)}$) is a topical antiseptic, commonly used over-the-counter drug for vaginitis, thrush and stomatitis. This drug is highly acidic with pH 0.6, and can act as a strong corrosive agent to oral mucosa. When inadvertently used in oral cavity, it may cause chemical burns of oral mucosa, resulting necrosis and bleeding surface resembling to erythema multifome. A 56 years old female patient presented with the chief complaints of painful ulcerations on the tongue, the upper and lower lips. On intraoral examination, an erythromatous, erosive or ulcerative surface covered with inflammatory exudates or bleeding crust is observed on the anterior half of the tongue and the upper and lower lips. She has occasionally applied the policresulen solution topically on the tongue to relieve pain from recurrent focal glossitis for about 10 years. In this time she applied it broadly and repeatedly to the tongue, the upper and lower lips for the purpose of pain relief by herself without instruction by physician or dentist. After cessation of policresulen application, the oral mucosa was rapidly recovered with use of topical steroids. In 2 weeks the lesions subsided completely. In summary, inadvertent use of $Albothyl^{(R)}$ on oral mucosa may result in chemical burn, causing mucosal erosion, ulceration and inflammation. It can be recovered by topical use of corticosteroid for 2 weeks after cessation of using $Albothyl^{(R)}$.


  1. Mundoor M, Prakash P, Sanupa S. Tetracyline hydrochloride chemical burn as self-inflicted mucogingival injury : a rare case report. Journal of Indian Society of Periodontology 2012;16:282-285.
  2. Shah M, Shah P, Parikh K. Aspirin induced chemical burn of oral mucosa - a case report. Journal of Dental Sciences volume 3 issue 1 41-42.
  3. Palao R, Monge I, Ruiz M, et al. Chemical burns: Pathophysiology and treatment. Burns. 2010 May; 36(3):295-304
  4. Dillek A, Süleyman B, Bulent G. A chemical erythematous macule of the buccal mucosa. Hacettepe Dishekimligi Fakultesi Dergisi. 2006 Cilt:30, Sayi: 1, Sayfa:63-66.
  5. Toon MH, Maybauer DM, Arceneaux LL et al. Children with burn injuries-assessment of trauma, neglect, violence and abuse. J Inj Violence Res. 2011 Jul;3:98-110.
  6. Nahlieli O, Eliav E, Shapira Y, et al. Central palatal burns associated with the eating of microwaved pizzas. Burns. 1999 Aug;25:465-6.
  7. Malcolm A, Vernon J, Martin S. Burket's Oral Medicine 9th ed. Philadelphia, 1994, J.B. Lippincott Co. p58-60.
  8. Canady JW, Thompson SA, Bardach J. Oral commissure burns in children. Plast Reconstr Surg. 1996:97(4):738-744.
  9. Dilsiz A. Self-inflicted oral soft-tissue burn due to local behavior and treatment. J Clin Exp Dent. 2010;2:e51-4.
  10. Murdoch-Kinch CA, Mallatt ME, Miles DA. Oral mucosal injury caused by denture cleanser tablets. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Dec;80:756-758.
  11. Nikitakis N, Titsinides S, Tosios K. Oral Medicine and Patohology Quiz- Case 13, Archives of Hellenic medicine. 2010.27.570-571.
  12. Ueda Masashi, Hirose Munetaka, Takei Nonuyuki et al. Nerve growth factor induces systemic hyperalgesia after thoracic burn injury in the rat. Neurosci Lett. 2002 Aug 9;328(2):97-100.
  13. Summer Gretchen J, Puntillo Kathleen A, Miaskowski Christine, et al. TrkA and PKC-epsilon in thermal burn-induced mechanical hyperalgesia in the rat. J Pain. 2006 Dec;7(12):884-91.
  14. Summer GJ, Puntillo KA, Miaskowski C, et al. Burn Injury Pain : The Continuing Challenge. J Pain Jul;8:533-48.
  15. Wood NK, Goaz PW. Differential Diagnosis of Oral and Maxillofacial Lesions, 5th ed. Mosby, 1997, p120-121.
  16. Yilmaz HH, Gormez O, Hastar E, et al. Garlic burn in a patient with trigeminal neuralgia: A case report. Eur J Dent. 2010;4:88-90.
  17. Norman K, Paul W, 구강 질환의 감별진단 4판, 1995, 지성출판사, p169-170.

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