One Pot Synthesis of Bioactive Novel Cyanopyridones

  • Khokhani, Kamlesh ;
  • Khatri, Taslimahemad ;
  • Patel, Praful
  • Received : 2013.04.09
  • Accepted : 2013.07.15
  • Published : 2013.08.20


Cyanopyridone was prepared by the condensation of cyanoacetamide, substituted arylaldehydes and malononitrile in presence of pipyridine. The structure of the synthesized compound CP 1-20 was assigned on the basis of elemental analysis, IR, $^1H$-NMR and mass spectroscopy. These compounds were also screened for antimicrobial activity. The Minimum Inhibitory Concentration (MIC) of all the synthesized compounds was compared with standard drugs.


Cyanopyrimidones;Cyanoacetamide;Antimicrobial activity;Malononitrile;Pipyridine


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