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Efficacy and clinical trials of Salenvac-T, bivalent killed vaccine containing Salmonella Enteritidis and Salmonella Typhimurium

Salmonella Enteritidis 및 Salmonella Typhimurium을 함유한 이가 불활화백신인 Salenvac-T의 방어효과 및 임상연구

  • Cho, Youngjae (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Kang, Zheng-Wu (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Kang, Kyung-Soo (Dongducheon Bayel Animal Clinic) ;
  • Jeong, Seunghwan (Intervet (MSD AH) Korea) ;
  • Yoon, Hee-Jun (Kangwon Veterinary Clinic) ;
  • Suh, Seungwon (Intervet (MSD AH) Korea) ;
  • Hahn, Tae-Wook (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University)
  • 조영재 (강원대학교 수의과대학 및 동물의학종합연구소) ;
  • 강정무 (강원대학교 수의과대학 및 동물의학종합연구소) ;
  • 강경수 (동두천바이엘) ;
  • 정승환 (인터베트코리아(주)) ;
  • 윤희준 (강원가축병원) ;
  • 서승원 (인터베트코리아(주)) ;
  • 한태욱 (강원대학교 수의과대학 및 동물의학종합연구소)
  • Received : 2012.10.23
  • Accepted : 2013.01.14
  • Published : 2013.03.31

Abstract

Commercial bivalent killed Salmonella vaccine Salenvac-T has been used in several countries in order to prevent salmonellosis with Salmonella enterica serovars Enteritidis (SE) and Typhimurium (ST) in poultry. However, this vaccine has not been used in poultry farms in South Korea. In this study, we evaluated the efficacy of Salenvac-T vaccine to protect against the challenge of virulent SE and ST, and the effect of the vaccine on egg production and mortality in layer hens. The colonization of liver, spleen and cecum with challenged SE and ST was reduced in vaccinated chickens compared with that of unvaccinated control group. The twice vaccination with Salenvac-T induced elevated antibody responses against both SE and ST detected by enzyme-linked immunosorbent assay (ELISA). The higher average hen-day production was observed in the vaccinated layer hens than in the unvaccinated layer hens without significance. The average mortality was lower in the vaccinated layer hens during the experiment period. The antibody responses to both SE and ST were persistently detected in the vaccinated layers. In summary, vaccination with Salenvac-T reduces colonization of internal organs and induces good antibody responses, thereby results in higher performance and lower egg contamination with SE and ST in layer hens.

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