Temporospatial clustering analysis of foot-and-mouth disease transmission in South Korea, 2010~2011

시공간 클러스터링 분석을 이용한 2010~2011 국내 발생 구제역 전파양상

  • Bae, Sun-Hak (College of Education, Kangwon National University) ;
  • Shin, Yeun-Kyung (Animal, Plant and Fisheries Quarantine and Inspection Agency) ;
  • Kim, Byunghan (Animal, Plant and Fisheries Quarantine and Inspection Agency) ;
  • Pak, Son-Il (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University)
  • 배선학 (강원대학교 사범대학) ;
  • 신연경 (농림수산검역검사본부) ;
  • 김병한 (농림수산검역검사본부) ;
  • 박선일 (강원대학교 수의과대학 및 동물의학종합연구소)
  • Received : 2012.10.22
  • Accepted : 2013.02.04
  • Published : 2013.03.31


To investigate the transmission pattern of geographical area and temporal trends of the 2010~2011 foot-and-mouth disease (FMD) outbreaks in Korea, and to explore temporal intervals at which spatial clustering of FMD cases space-time analysis based on georeferenced database of 3,575 burial sites, from 30 November 2010 to 23 February 2011, was performed. The cases represent approximately 98.1% of all infected farms (n = 3,644) during the same period. Descriptive maps of spatial patterns of the outbreaks were generated by ArcGIS. Spatial Scan Statistics, using SaTScan software, was applied to investigate geographical clusters of FMD cases across the country. Overall, spatial heterogeneity was identified, and the transmission pattern was different by province. Cattle have more clusters in number but smaller in size, as compared to the swine population. In addition, spatiotemporal analysis and the comparison of clustering patterns between the first 7 days and days 8 to 14 of the outbreak revealed that the strongest spatial clustering was identified at the 7-day interval, although clustering over longer intervals (8~14 days) was also observed. We further discussed the importance of time period elapsed between FMD-suspected notice and the date of confirmation, and emphasized the necessity of region-specific and species-specific control measures.


Supported by : 농림수산검역검사본부


  1. Alkhamis MA, Perez AM, Yadin H, Knowles NJ. Temporospatial clustering of foot-and-mouth disease outbreaks in Israel and Palestine, 2006-2007. Transbound Emerg Dis 2009, 56, 99-107.
  2. Animal, Plant and Fisheries Quarantine and Inspection Agency (QIA). Epidemiological report of the 2010-2011 footand- mouth disease epidemic. pp. 209-274, QIA, Anyang, 2011.
  3. Carpenter TE, Thurmond MC, Bates TW. A simulation model of intraherd transmission of foot and mouth disease with reference to disease spread before and after clinical diagnosis. J Vet Diagn Invest 2004, 16, 11-16.
  4. Davies PR, Wayne SR, Torrison JL, Peele B, de Groot BD, Wray D. Real-time disease surveillance tools for the swine industry in Minnesota. Vet Ital 2007, 43, 731-738.
  5. Dunn CS, Donaldson AI. Natural adaption to pigs of a Taiwanese isolate of foot-and-mouth disease virus. Vet Rec 1997, 141, 174-175.
  6. Kandwal R, Garg PK, Garg RD. Health GIS and HIV/ AIDS studies: Perspective and retrospective. J Biomed Inform 2009, 42, 748-755.
  7. Kulldorff M, Heffernan R, Hartman J, Assunção R, Mostashari F. A space-time permutation scan statistic for disease outbreak detection. PLoS Med 2005, 2, e59.
  8. Le Menach A, Legrand J, Grais RF, Viboud C, Valleron AJ, Flahault A. Modeling spatial and temporal transmission of foot-and-mouth disease in France: identification of highrisk areas. Vet Res 2005, 36, 699-712.
  9. Lee YJ, Shin MS, Yoon HC, Chang WS, Hwang SC, Kim YJ, Jung JW, Lee SJ. Epidemiological characteristics about introduction and transmission of foot-and-mouth disease in republic of Korea in January 2010. Korean J Vet Public Health 2010, 34, 203-210.
  10. Madin B. An evaluation of foot-and-mouth disease outbreak reporting in mainland South-East Asia from 2000 to 2010. Prev Vet Med 2011, 102, 230-241.
  11. McLaws M, Ribble C, Martin W, Stephen C. Factors associated with the clinical diagnosis of foot and mouth disease during the 2001 epidemic in the UK. Prev Vet Med 2006, 77, 65-81.
  12. McNally RJQ, Alexander FE, Bithell JF. Space-time clustering of childhood cancer in great Britain: a national study, 1969-1993. Int J Cancer 2006, 118, 2840-2846.
  13. Ministry of Public Administration and Security. Report on the foot-and-mouth disease epidemic. pp. 721-724, Ministry of Public Administration and Security, Seoul, 2011.
  14. Perez AM, Zeng D, Tseng CJ, Chen H, Whedbee Z, Paton D, Thurmond MC. A web-based system for near real-time surveillance and space-time cluster analysis of foot-andmouth disease and other animal diseases. Prev Vet Med 2009, 91, 39-45.
  15. Sobrino F, Saiz M, Jimenez-Clavero MA, Nunez JI, Rosas MF, Baranowski E, Ley V. Foot-and-mouth disease virus: a long known virus, but a current threat. Vet Res 2001, 32, 1-30.
  16. Yang PC, Chu RM, Chung WB, Sung HT. Epidemiological characteristics and financial costs of the 1997 foot-and-mouth disease epidemic in Taiwan. Vet Rec 1999, 145, 731-734.

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