Hepatic extraskeletal osteosarcoma with systemic metastasis in a dog

  • Johnson, Crystal (Charles River Laboratories, Inc) ;
  • Kim, Yongbaek (The Laboratory of Clinical Pathology and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University)
  • Received : 2012.10.05
  • Accepted : 2012.12.10
  • Published : 2013.03.31


A ten-year-old dog was presented with pancreatitis and increased hepatic enzymes. On necropsy a large firm mass was observed in the liver extending to the gall bladder. Smaller masses with similar texture were found in multiple organs including lung, stomach, pancreas, lymph nodes, omentum, and mesentery. Neoplastic cells were spindle shaped with prominent osteoid production and occasional trabeculae of woven bone. Tumor cell emboli were observed in the blood vessels and lymphatics of the omentum and stomach. Hepatic osteosarcoma with systemic metastasis is very rare and may serve to broaden the diagnostic spectrum of hepatic and pancreatic diseases in dogs.


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