Clinical evaluation of bleaching effect of 3% hydrogen peroxide strip with primer on human enamel

3% hydrogen peroxide 자가미백 부착대와 프라이머 겸용에 의한 치아미백 효과 평가

Yang, Hae-Young;Kim, Eun-Kyong;Choi, Sung-Suk;Cho, Min-Jeong;Lee, Young-Eun;Yoon, Ho-Young;Song, Keun-Bae

  • Received : 2013.08.28
  • Accepted : 2013.10.18
  • Published : 2013.10.31


Objectives : The purpose of this study was to evaluate the bleaching effect of 3% hydrogen peroxide containing strip with primer in vivo. Methods : 22 female subjects aged from 20 to 39 years old were recruited after informed consent. They were divided into two groups with control and experimental group. Experimental group was bleached with 3% HP strip with primer, and control group received placebo for 14 days. Color changes were measured with Shade Eye-NCC (Shade Eye-NCC, SHOFU Co., Japan), Shade guide (VITA classical shade guide, $VIDENT^{TM}$, CA, USA) and digital camera image. All collected data were analyzed using SPSS 18.0. Results : At baseline, $L^*$ was $71.75{\pm}3.2$ and $b^*$ was $14.90{\pm}3.6$ in control, and $L^*$ was $71.3{\pm}3.4$ and $b^*$ was $15.61{\pm}3.7$ in experimental group. At day 14, $L^*$ was $71.35{\pm}3.2$ and $b^*$ was $13.97{\pm}4.3$ in control, and $L^*$ was $73.51{\pm}2.0$, $b^*$ was $9.10{\pm}3.0$ in experimental group. ${\Delta}E^*$ of all teeth were statistically significant between the two groups. Final ${\Delta}E^*$ was $7.15{\pm}2.09$ at experimental group and $2.78{\pm}2.93$ at control group, and the difference was significant (p<0.005). Color changes using shade guide also significantly decreased at 14th day compared with baseline at experimental group (p<0.005). Conclusions : 3% hydrogen peroxide strip with primer revealed effective enough to bleaching the human enamel during 14 days without any soft and hard tissue irritations.


bleaching;hydrogen peroxide;primer;strip


  1. Andrew J. Tooth colour: a review of the literature. J Dent 2004; 32(suppl): 3-12.
  2. Watts A, Addy M. Tooth discolouration and staining: a review of literature. Br Dent J 2001; 190(6): 309-16.
  3. Feinman RA, Goldstein RE, Garber DA. Bleaching teeth. Chicago: Quintessence; 1987; 9.
  4. Nordbo H. Discoloration of dental pellicle by tannic acid. Acta Odontol Scand 1977; 35(6): 305-10.
  5. Addy M, Moran J. Extrinsic tooth discoloration by metals and chlorhexidine: II. Clinical staining produced by chlorhexidine, iron and tea. Br Dent J 1985; 159(10): 331-4.
  6. Eriksen HM, Nordbo H. Extrinsic discoloration of teeth. J Clin Periodontal 1978; 5(3): 286-96.
  7. Nutting EB, Poe GS. A new combination for bleaching teeth. J South Calif Dent Assoc 1963; 31(9): 289-91.
  8. Lopes GC, Bonissoni L, Baratieri LN, Vieira LC, Monterio S Jr. Effect of bleaching agents on the hardness and morphology of enamel. J Esthet Restor Dent 2002; 14(1): 24-30.
  9. Nutting EB, Poe GS. A new combination for bleaching teeth. J South Calif Dent Assoc 1963; 31(9): 289-91.
  10. Jung SH, Park DY, Ma DS. Efficacy of six months of a 2.6% hydrogen peroxide containing tooth-whitening strips. J Korean Acad Oral Health 2004; 28(1): 117-25.
  11. Clark DM, Hintz J. Case report: in-office tooth whitening procedure with 35% carbamide peroxide evaluated by the minolta CR-321 chroma meter. J Esthet Dent 1998; 10(1): 37-42.
  12. Basting RT, Amaral FL, Franca FM, Florio FM. Clinical comparative study of the effectiveness of and tooth sensitivity to 10% and 20% carbamide peroxide home-use and 35% and 38% hydrogen peroxide in-office bleaching materials containing desensitizing agents. Oper Dent 2012; 37(5): 464-73.
  13. Da Costa J, Lubisich E, Ferracane J, Hilton T. Comparison of efficacy of an in-office whitening system used with and without a whitening priming agent. J Esthet Restor Dent 2011; 23(2): 97-104.
  14. Moraes PR, Marimon JL, Schneider LF, Correr Sobrino L, Camacho GB, Bueno M. Carbamide peroxide bleaching agents: effects on surface roughness of enamel, composite and porcelain. Clin Oral Investing 2006; 10(1): 23-8.
  15. Rosenstiehl SF, Gegauff AG, Johnston WM. Randomized clinical trial of the efficacy and safety of a home bleaching procedure. Quintessence Int 1996; 27(6): 413-24.
  16. Wiegand A, Vollmer D, Foitzic M, Attin R, Attin T. Efficacy of different whitening modalities on bovine enamel and dentin. Clin Oral Investing 2005; 9(2): 91-7.
  17. Lee SY, Jeong SH, Kang SM, Kwon HK, Kim BI. Effect of 2.8% hydrogen peroxide gel on tooth whitening in vitro. J Korean Acad Oral Health 2007; 31(1): 20-30.
  18. Shim YS. The effect of tooth bleaching agent contained 35% hydrogen peroxide on the color, microhardness and surface roughness of tooth-colored restorative materials. J Korean Soc of Dent Hygiene 2012; 12(3): 533-41.
  19. Geralch RW, Gibb RD, Sagel PA. A randomized clinical trial comparing a novel 5.3% hydrogen peroxide whitening strip to 10%, 15%, and 20% carbamide peroxide tray-based bleaching system. Compend Contin Educ Dent 2000; 21(29): S22-8.
  20. Gerlach RW, Zhou X. Comparative clinical efficacy of two professional bleaching systems. Compend Contin Educ Dent 2002; 23(1A): 35-41.
  21. Lenhard M. Assessing tooth color change after repeated bleaching in vitro with a 10 percent carbamide peroxide gel. J Am Dent Assoc 1996; 127(11): 1618-24.
  22. Shotwell JL, Razzoong ME, Koran A. Color stability of longterm soft denture liners. J Proshet Dent 1992; 68(5): 836-8.
  23. Gregus Z, Klaassen CD. Mechanisms of toxicity. In: Cssarett and Doull's Toxicology, the basic science of poisons. Kaassen CD. ed. 3rd ed. New York: McGraw-Hill Companies Inc; 1986: 35-74.
  24. Cotton FA, Wilkinson G. Oxygen. In: Advances in inorganic chemistry: a comprehensive text. Cotton FA, Wilkinson G. eds. New York: Interscience; 1966: 403-20.
  25. Wetter NU, Branco EP, Deana AM, Pelino JE. Color differences of canines and incisors in a comparative long-term clinical trial of three bleaching systems. Lasers Med Sci 2009; 24(6): 941-7.
  26. Ruyter IE, Nilner K, Moller B. Color stability of dental composite resin materials for crown and bridge veneers. Dent Mater 1987; 3(5): 246-51.
  27. Johnston WM, Kao EC. Assessment of appearance match by visual observation and clinical colorimetry. J Dent Res 1989; 68(5): 819-22.