- Volume 54 Issue 4
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Stimulatory effects of Bordetella bronchiseptica antigen on bone marrow cells and immune memory responses
골수세포에 대한 Bordetella bronchiseptica 항원의 자극 효과 및 면역기억반응
- Yim, Seol-Hwa (Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Jeju National University) ;
- Joo, Hong-Gu (Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Jeju National University)
- Received : 2014.06.26
- Accepted : 2014.10.13
- Published : 2014.12.31
Bone marrow is a hematological and immunological organ that provides multiple immune cells, including B lymphocytes, and thus plays a critical role in the efficacy of vaccine. We previously demonstrated that Bordetella (B.) bronchiseptica antigen has high immunogenicity in spleen cells, a peripheral immune organ. In this study, we investigated the immunogenicity of B. bronchiseptica antigen in bone marrow cells, a central immune organ. B. bronchiseptica antigen increased the cellular activity of bone marrow cells and significantly enhanced the production of nitric oxide, IL-6, and TNF-
Supported by : 농림축산식품부
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