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Effect of Dietary Supplementation of Procyanidin on Growth Performance and Immune Response in Pigs

  • Park, J.C. (National Institute of Animal Science, R.D.A.) ;
  • Lee, S.H. (National Institute of Animal Science, R.D.A.) ;
  • Hong, J.K. (National Institute of Animal Science, R.D.A.) ;
  • Cho, J.H. (Department of Animal Resource and Science, Dankook University) ;
  • Kim, I.H. (Department of Animal Resource and Science, Dankook University) ;
  • Park, S.K. (National Institute of Animal Science, R.D.A.)
  • Received : 2013.05.24
  • Accepted : 2013.10.11
  • Published : 2014.01.01

Abstract

This study was performed to determine the effect of dietary supplementation of procyanidin on growth performance, blood characteristics, and immune function in growing pigs. In experiment 1 (Exp. 1), thirty-two crossbred pigs with an initial BW of $19.2{\pm}0.3$ kg were allocated into 4 treatments for an 8-wk experiment: i) CON (basal diet), ii) MOS 0.1 (basal diet+0.1% mannanoligosaccharide), iii) Pro-1 (basal diet+0.01% procyanidin), and iv) Pro-2 (basal diet+0.02% procyanidin). Pigs fed Pro-1 and Pro-2 diets had greater (p<0.05) gain:feed ratio compared with those fed CON or MOS 0.1 diets. Serum creatinine concentration was less (p<0.05) in Pro-2 treatment than those in CON, MOS 0.1 and Pro-1 treatments. In Exp. 2, twelve pigs (BW $13.4{\pm}1.3$ kg) received basal diet with i) 0 (CON), ii) 0.02% (Pro-0.02%), and iii) 0.04% procyanidin (Pro-0.04%) for 4 wk. Concentration of platelets was lower (p<0.05) in the Pro-0.04% group compared to CON at 24 h after lipopolysaccharide (LPS) challenge. In addition, secretion of cytokines from cultured peripheral blood mononuclear cells (PBMC) in the presence or absence of procyanidin was examined. The levels of interleukin (IL)-$1{\beta}$, IL-6 and tumor necrosis factor (TNF)-${\alpha}$ were lower (p<0.05) in Pro (LPS-stimulated PBMCs+procyanidin) than those in CON (LPS-stimulated PBMCs+PBS) at 4 h after LPS challenge. These data suggest that dietary addition of procyanidin improves feed efficiency and anti-inflammatory cytokines of pigs.

Keywords

Growth Performance;Immune Response;Lipopolysaccharide;Pigs;Procyanidin

Acknowledgement

Grant : cooperative research program for Agriculture Science & Technology Development

Supported by : Rural Development Administration

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