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Anti-inflammatory Activity of Onion Juice Prepared from Sulfur-Fertilized Onions in High Glucose Induced Human Monocytes

고혈당으로 유도된 염증반응 모델에서 유황양파즙의 항염증 효능 평가

  • Yun, Jung-Mi (Department of Food and Nutrition, Kwangju Women's University) ;
  • Surh, Jeonghee (Department of Food and Nutrition, Kangwon National University)
  • 윤정미 (광주여자대학교 식품영양학과) ;
  • 서정희 (강원대학교 식품영양학과)
  • Received : 2014.08.30
  • Accepted : 2014.10.16
  • Published : 2014.12.31

Abstract

The anti-inflammatory activity of onion juices prepared from sulfur-fertilized onions was investigated by measuring the secretion of proinflammatory cytokines from human monocytes cultured under hyperglycemic condition. Human monocytic (THP-1) cells were cultured under normoglycemic (NG, 5.5 mM glucose) or hyperglycemic (HG, 25 mM glucose) conditions, with or without onion juice. Without onion juice, cell viability decreased significantly in the HG state for 48 h, compared to that in the NG state. With onion juice ($50-150{\mu}L$) treatment, the cell viability was not different from that under the NG condition, suggesting that onion juice prevented HG-induced monocytes cytotoxicity. While the HG condition in vitro significantly induced TNF-${\alpha}$ release from THP-1 cells and its gene expression, onion juice ($50{\mu}L$) significantly suppressed them. This indicates that onion juice inhibited HG-induced cytokine production in monocytes. These results suggest that onion juice from sulfur-fertilized onions can be used for the prevention of diabetes and related diseases.

Keywords

onion juice;anti-inflammatory;high glucose;diabetes

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