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Protective Effect of Citrus unshiu Peel Extract on Ethanol-Induced Fatty Liver in Rats

흰쥐에서 감귤과피 추출물의 알코올성 지방간 개선 작용

  • Kim, Juyeon (Dept. of Food and Nutrition, Changwon National University) ;
  • Choi, In-Wook (Korea Food Research Institute) ;
  • Noh, Sang Kyu (Dept. of Food and Nutrition, Changwon National University)
  • 김주연 (국립창원대학교 식품영양학과) ;
  • 최인욱 (한국식품연구원) ;
  • 노상규 (국립창원대학교 식품영양학과)
  • Received : 2013.11.21
  • Accepted : 2013.11.29
  • Published : 2014.02.28

Abstract

This study investigated whether or not Citrus unshiu peel extract (CPE) affects fat accumulation in livers of rats fed an ethanol-containing liquid diet. Initially, male Sprague-Dawley rats were housed individually in stainless steel, wire-bottomed cages with free access to a Lieber-Decarli control liquid diet. Rats were divided by body weight into three groups of eight each: one group of rats was fed the Lieber-Decarli control liquid diet devoid of ethanol (control), another was fed the Lieber-Decarli ethanol diet (ethanol), and third was fed the same ethanol diet except containing CPE. All three groups were fed their respective diets for 6 weeks. Serum and liver lipids were analyzed and liver histology performed. Body weight did not differ among the groups over the 6-wk duration. Histology images showed that CPE administration significantly improved fat accumulation in livers, which was induced by ethanol diet. Serum levels of transaminases and lipids also were reduced by CPE consumption. Taken together, the results indicate that CPE may protect ethanol-induced fatty liver by lowering fat accumulation in both the liver and blood. The protective effects of CPE appear to be due to its phenolic contents.

Acknowledgement

Supported by : 한국식품연구원

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