표고버섯이 고지방식이로 유도한 비만 흰쥐에 미치는 항비만 효과

Anti-Obesity Effects of Lentinus edodes on Obese Mice Induced by High Fat Diet

  • Lee, Mi Ra (Dept. of Food Science and Technology, Chungnam National University) ;
  • Oh, Deuk Sil (Jeollanam-do Forest Resource Research Institute) ;
  • Wee, An Jin (Jeollanam-do Forest Resource Research Institute) ;
  • Yun, Byung Sun (Jeollanam-do Forest Resource Research Institute) ;
  • Jang, Soon Ae (Hanbat University Industry Collaboration Foundation) ;
  • Sung, Chang Keun (Dept. of Food Science and Technology, Chungnam National University)
  • 투고 : 2013.09.27
  • 심사 : 2013.10.24
  • 발행 : 2014.02.28


본 연구는 표고버섯 물추출물의 항비만 효과를 알아보기 위하여 6주령의 수컷 C57BL/6 마우스를 이용하여 고지방식이와 함께 표고버섯 물추출 분말을 1%, 3%, 5% 수준으로 첨가하여 12주간 공급하였다. 고지방 식이섭취는 체중, 혈청지질 농도 및 지방조직 무게를 증가시켰다. 표고버섯 물추출물 섭취는 고지방식이로 증가된 혈청 총콜레스테롤, 중성지방, LDL-콜레스테롤 농도를 현저히 감소시켜 대조군보다 더 낮은 값을 나타냈다. 또한 5% 표고버섯 물추출물 첨가군은 고지방 식이군보다 체중 및 피하지방량이 현저히 감소하였다. 변배설량은 3%와 5% 표고버섯 물추출물 첨가군에서 고지방 식이군보다 현저히 증가하였다. 표고버섯 물추출물 섭취는 고지방식이로 인해 증가된 간조직의 지방축적과 지질과산화물 형성을 억제하였으며, 특히 5% 표고버섯 물추출물 섭취군에서 지질과산화물 형성이 유의적으로 감소되었고 총 항산화 활성도 유의적으로 가장 높게 나타났다. 고지방식이군은 간조직의 조직염색에서 지방간이 심하게 진행된 것이 발견되었고, 표고버섯 물추출물 섭취군은 지방세포에 지방이 침투하지 않은 간지방증 소견을 보였다. 위의 결과를 통하여 볼 때 표고버섯은 체중 및 체지방 감소, 그리고 혈청지방 농도 개선에 효과가 있어 비만관리에 도움을 주는 것으로 사료된다.


연구 과제 주관 기관 : 전라남도 산림자원연구소


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