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건강기능식품의 기능성을 중심으로 한 글루코사민의 관절건강 기능성에 대한 체계적 고찰

Systematic Review of the Effect of Glucosamine on Joint Health while Focused on the Evaluation of Claims for Health Functional Food

  • 김주희 (이화여자대학교 바이오푸드네트워크) ;
  • 김지연 (서울과학기술대학교 식품공학과) ;
  • 곽진숙 (주식회사 바이오푸드씨알오) ;
  • 백주은 (주식회사 바이오푸드씨알오) ;
  • 정세원 (이화여자대학교 바이오푸드네트워크) ;
  • 권오란 (이화여자대학교 바이오푸드네트워크)
  • Kim, Joohee (Biofood Network Center, Ewha Womans University) ;
  • Kim, Ji Yeon (Dept. of Food Science and Technology, Seoul National University of Science and Technology) ;
  • Kwak, Jin Sook (Biofood CRO Co., Ltd.) ;
  • Paek, Ju Eun (Biofood CRO Co., Ltd.) ;
  • Jeong, Sewon (Biofood Network Center, Ewha Womans University) ;
  • Kwon, Oran (Biofood Network Center, Ewha Womans University)
  • 투고 : 2013.07.10
  • 심사 : 2013.10.01
  • 발행 : 2014.02.28

초록

글루코사민의 관절건강 기능성을 건강기능식품 재평가 기준에 맞추어 체계적 고찰을 실시하였다. 2012년 5월 기준 DB 검색을 통해 703건의 자료를 수집하여, 선정/제외 기준에 따라 선별한 결과 총 34건의 연구가 평가되었다. 34건 중 28건(4,225명)의 연구에서 통계적으로 유의한 개선 효과가 나타났으며(P<0.05), 일일 섭취량은 1.5~2 g으로 공전에서 제시되어 있는 섭취량 범위에 해당하였다. 글루코사민의 기능성 재평가 이후의 연구 결과는 16건이었고, 이 중 1,158명 대상 14건의 연구에서 유의한 관절건강 개선효과를 보였다(P<0.05). 연구대상자에 따른 분석 결과, 방사선 검사 기준에 따라 관절 연골의 손상 정도가 심한 대상자를 제외한 연구는 11건이었으며, 이 중 2,934명 대상 10건의 연구에서 글루코사민이 관절건강에 유의한 개선 효과를 보였다(P<0.05). 따라서 현시점에서 건강기능식품인 글루코사민의 관절건강 기능성은 인정될 것으로 판단되나 향후 연구 결과 추이를 지속적으로 지켜볼 필요가 있다.

과제정보

연구 과제 주관 기관 : 식품의약품안전처

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