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Inhibitory Effect of Curcuma longa L. Extracts on 5-Alpha Reductase II Activity

울금 추출물의 5-Alpha Reductase II 활성 저해 효과

  • Received : 2013.10.02
  • Accepted : 2014.01.22
  • Published : 2014.02.28

Abstract

5-Alpha reductase II, which converts testosterone (T) to dihydrotestosterone (DHT), is a crucial enzyme II in benign prostatic hyperplasia. Inhibitory effects of Curcuma longa L. (CL) extracts on 5-alpha reductase II activity were investigated in rat prostate tissue homogenates as well as LNCaP cells expressing human 5-alpha reductase II. Hot water extract (CL-HW) of Curcuma longa L. significantly inhibited 5-alpha reductase activity by over 80% at a concentration of $100{\mu}g/mL$, whereas 20% ethanol extracts (CL-E20) of Curcuma longa L. exhibited significant inhibitory activity from $50{\mu}g/mL$. These results indicated that Curcuma longa L is a potent 5-alpha reductase II inhibitor for benign prostatic hyperplasia treatment.

Acknowledgement

Supported by : 농림수산식품부

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