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The Pharmacological Activity of Coffee Fermented Using Monascus purpureus Mycelium Solid-state Culture Depends on the Cultivation Area and Green Coffees Variety

원산지 및 품종에 따라 조제된 홍국균 균사체-고체발효 원두커피의 생리활성

  • Received : 2013.07.18
  • Accepted : 2013.11.22
  • Published : 2014.02.28

Abstract

In previous work, we fermented coffee beans using solid-state culture with various fungal mycelia to enhance the physiological activity of the coffee. The coffee fermented with Monascus sp. showed a higher physiological activity than non-fermented coffee or other coffees fermented with mushroom mycelium. The aim of this study was to characterize the various fermented coffees with respect to their area of cultivation and their variety using Monascus purpureus (MP) mycelium solid-state culture. Thirty types of green coffee beans, which varied in terms of their cultivation area or variety, were purchased from different suppliers and fermented with MP under optimal conditions. Each MP-fermented coffee was medium roasted and extracted further using hot water (HW) under the same conditions. Of the HW extracts, those derived from MP-Mandheling coffees had the highest yield (13.6-15.5%), and MP-Robusta coffee showed a significantly higher polyphenolic content (3.03 mg gallic acid equivalent/100 mg) and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) free radical scavenging activity (27.11 mg ascorbic acid equivalent antioxidant capacity/100 mg). Furthermore, in comparison to other MP-fermented coffees at $1,000{\mu}g/mL$, MP-Robusta coffee showed not only the most effective inhibition of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) production in LPS-stimulated RAW 264.7 cells (67.1% of that in LPS-stimulated control cells), but also an effective inhibition of lipogenesis in 3T3-L1 adipose cells (22.2% of that in differentiated control cells). In conclusion, these results suggest that Vietnam Robusta coffee beans solid-state fermented with MP mycelium are amenable to industrial applications as a functional coffee beverage or material.

Keywords

Monascus purpureus;solid-state culture;pharmacological activity;arabica coffee;robusta coffee

References

  1. Brezova V, Slebodova A, Stasko A. Coffee as a source of antioxidants: An EPR study. Food Chem. 114: 859-868 (2009) https://doi.org/10.1016/j.foodchem.2008.10.025
  2. Esquivel P, Jimenez VM. Functional properties of coffee and coffee by-products. Food Res. Int. 46: 488-495 (2012) https://doi.org/10.1016/j.foodres.2011.05.028
  3. Kim MJ, Park JE, Lee JH, Choi NR, Hong MH, Pyo YH. Antioxidant capacity and bioactive composition of a single serving size of regular coffee varieties commercially available in Korea. Korean J. Food Sci. Technol. 45: 299-304 (2013) https://doi.org/10.9721/KJFST.2013.45.3.299
  4. Chu YF, Brown PH, Lyle BJ, Chen Y, Black RM, Williams CE, Lin YC, Hsu CW, Cheng IH. Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees. J. Agr. Food Chem. 57: 9801-9808 (2009) https://doi.org/10.1021/jf902095z
  5. Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M. Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J. Alzheimer's Dis. 16: 85-91 (2009)
  6. Hu G, Bidel S, Jousilahti P, Antikainen R, Tuomilehto J. Coffee and tea consumption and the risk of Parkinson's disease. Mov. Disord. 22: 2242-2248 (2007) https://doi.org/10.1002/mds.21706
  7. Klatsky AL, Morton C, Udaltsova N, Friedman GD. Coffee, cirrhosis, and transaminase enzymes. Arch. Intern. Med. 166: 1190-1195 (2006) https://doi.org/10.1001/archinte.166.11.1190
  8. Chu YF, Chen Y, Black RM, Brown PH, Lyle BJ, Liu RH, Ou B. Type 2 diabetes-related bioactivities of coffee: Assessment of antioxidant activity, NF-B inhibition, and stimulation of glucose uptake. Food Chem. 124: 914-920 (2011) https://doi.org/10.1016/j.foodchem.2010.07.019
  9. Choi EY, Jang JY, Cho YO. Coffee intake can promote activity of antioxidant enzymes with increasing MDA level and decreasing HDL-cholesterol in physically trained rats. Nutr. Res. Pract. 4: 283-289 (2010) https://doi.org/10.4162/nrp.2010.4.4.283
  10. Chou T. Wake up and smell the coffee. Caffeine, coffee and the medical consequences. West J. Med. 157: 544-553 (1992)
  11. Lopez-Garcia E, van Dam RM, Willett WC, Rimm EB, Manson JE, Stampfer MJ, Rexrode KM, Hu FB. Coffee consumption and coronary heart disease in men and women: a prospective cohort study. Circulation 113: 2045-2053 (2006) https://doi.org/10.1161/CIRCULATIONAHA.105.598664
  12. Kang KJ, Choi SS, Han HK, Kim KH, Kwon SS. Effects of instant coffee on weight, plasma lipids, leptin, and fat cell size in rats fed on a high fat diet. Korean J. Food Sci. Technol. 36: 478-483 (2004)
  13. Mackay DC, Rollins JW. Caffeine and caffeinism. J. R. Nav. Med. Serv. 75: 65-67 (1989)
  14. Yano K, Rhoads GG, Kagan A. Coffee, alcohol and risk of coronary heart disease among Japanese men living in Hawaii. N. Engl. J. Med. 297: 405-409 (1977) https://doi.org/10.1056/NEJM197708252970801
  15. LaCroix AZ, Mead LA, Liang KY, Thomas CB, Pearson TA. Coffee consumption and the incidence of coronary heart disease. N. Engl. J. Med. 315: 977-982 (1986) https://doi.org/10.1056/NEJM198610163151601
  16. Ma J, Li Y, Ye Q, Li J, Hua Y, Ju D, Zhang D, Cooper R, Chang M. Constituents of red yeast rice, a traditional Chinese food and medicine. J. Agr. Food Chem. 48: 5220-5225 (2000) https://doi.org/10.1021/jf000338c
  17. Donahue RP, Orchard TJ, Stein EA, Kuller LH. Lack of an association between coffee consumption and lipoprotein lipids and apolipoproteins in young adults: The Beaver County Study. Prev. Med. 16: 796-802 (1987) https://doi.org/10.1016/0091-7435(87)90019-3
  18. de Roos B, Sawyer JK, Katan MB, Rudel LL. Validity of animal models for the cholesterol-raising effects of coffee diterpenes in human subjects. Proc. Nutr. Soc. 58: 551-557 (1999) https://doi.org/10.1017/S0029665199000725
  19. Blanc PJ, Loret MO, Santerre AL, Pareilleux A, Prome D, Prome JC, Laussac JP, Goma G. Pigments of Monascus. J. Food Sci. 59: 862-864 (1994) https://doi.org/10.1111/j.1365-2621.1994.tb08145.x
  20. Endo A. Monacolin-K, a new hypocholesterolemic agent produced by Monascus species. J. Antibiot. 32: 852-854 (1979) https://doi.org/10.7164/antibiotics.32.852
  21. Manzoni M, Rollini M. Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. Appl. Mocrobiol. Biotechnol. 58: 555-564 (2002) https://doi.org/10.1007/s00253-002-0932-9
  22. Wang IK, Lin-Shiau SY, Chen PC, Lin JK. Hypotriglyceridemic effect of Anka (a fermented rice product of Monascus sp.) in rats. J. Agr. Food Chem. 48: 3183-3189 (2000) https://doi.org/10.1021/jf9909353
  23. Shin JY, Kim H, Kim DG, Baek GH, Jeong HS, Yu KW. Pharmacological activities of coffee roasted from fermented green coffee beans with fungal mycelia in solid-state culture. J. Korean Soc. Food Sci. Nutr. 42: 487-496 (2013) https://doi.org/10.3746/jkfn.2013.42.3.487
  24. Velioglu YS, Mazza G, Cao L, Oomah BD. Antioxidant activity and total phenolics in selected fruit, vegetables, and grain products. J. Agr. Food. Chem. 46: 4113-4117 (1998) https://doi.org/10.1021/jf9801973
  25. Hecimovic I, Belscak-Cvitanovic A, Horzic D, Komes D. Comparative study of polyphenols and caffeine in different coffee varieties affected by the degree of roasting. Food Chem. 129: 991-1000 (2011) https://doi.org/10.1016/j.foodchem.2011.05.059
  26. Choi Y, Lee SM, Chun J, Lee HB, Lee J. Influence of heat treatment on the antioxidant activities and polyphenolic compounds of shiitake (Lentinus edodes) mushroom. Food Chem. 99: 381-387 (2006) https://doi.org/10.1016/j.foodchem.2005.08.004
  27. Fox JB. Kinetics and mechanisms of the Griess reaction. Anal. Chem. 51: 1493-1502 (1979) https://doi.org/10.1021/ac50045a032
  28. Ishiyama M, Tominaga H, Shiga M, Sasamoto K, Ohkura Y, Ueno K. A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet. Biol. Pharm. Bull. 19: 1518-1520 (1996) https://doi.org/10.1248/bpb.19.1518
  29. Yen WJ, Wang BS, Chang LW, Duh PD. Antioxidant properties of roasted coffee residues. J. Agr. Food Chem. 53: 2658-2663 (2005) https://doi.org/10.1021/jf0402429
  30. Sato Y, Itagaki S, Kurokawa T, Ogura J, Kobayashi M, Hirano T, Sugawara M, Iseki K. In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. Int. J. Pharm. 403: 136-138 (2011) https://doi.org/10.1016/j.ijpharm.2010.09.035
  31. Trugo LC, Macrae R. A study of the effect of roasting on the chlorogenic acid composition of coffee using HPLC. Food Chem. 15: 219-229 (1984) https://doi.org/10.1016/0308-8146(84)90006-2
  32. Trugo LC, Macrae R. Chlorogenic acid composition of instant coffee. Analyst 109: 263-266 (1984) https://doi.org/10.1039/an9840900263
  33. Clifford MN, Jarvis T. The chlorogenic acids content of green robusta coffee beans as a possible index of geographic origin. Food Chem. 29: 291-298 (1988) https://doi.org/10.1016/0308-8146(88)90044-1
  34. Cho W, Nam JW, Kang HJ, Windono T, Seo EK, Lee KT. Zedoarondiol isolated from the rhizoma of Curcuma heyneana is involved in the inhibition of iNOS, COX-2 and pro-inflammatory cytokines via the downregulation of NF-B pathway in LPS-stimulated murine macrophages. Int. Immunopharmacol. 9: 1049-1057 (2009) https://doi.org/10.1016/j.intimp.2009.04.012
  35. Yun HJ, Heo SK, Yi HS, Kim CH, Kim BW, Park SD. Antiinflammatory effect of Injinho-tang in RAW 264.7 cells. Kor. J. Herbology 23: 169-178 (2008)
  36. Seymour RM, Henderson B. Pro-inflammatory-anti-inflammatory cytokine dynamics mediated by cytokine-receptor dynamics in monocytes. IMA J. Math. Appl. Med. Biol. 18: 159-192 (2001) https://doi.org/10.1093/imammb/18.2.159
  37. Cho AS, Jeon SM, Kim MJ, Yeo JY, Seo KI, Choi MS, Lee MK. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem. Toxicol. 48: 937-943 (2010) https://doi.org/10.1016/j.fct.2010.01.003
  38. Hsu CL, Huang SL, Yen GC. Inhibitory effect of phenolic acids on the proliferation of 3T3-L1 preadipocytes in relation to their antioxidant activity. J. Agr. Food Chem. 54: 4191-4197 (2006) https://doi.org/10.1021/jf0609882
  39. Endo A. Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J. Antibiot. 33: 334-336 (1980) https://doi.org/10.7164/antibiotics.33.334
  40. Endo A, Hasumi K, Negishi S. Monacolin J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber. J. Antibiot. 38: 420-422 (1985) https://doi.org/10.7164/antibiotics.38.420

Cited by

  1. Physiological Activity of Roasted Coffee prepared from Fermented Green Coffee Bean with Monascus ruber Mycelium vol.29, pp.1, 2016, https://doi.org/10.9799/ksfan.2016.29.1.001

Acknowledgement

Supported by : 중소기업청