Study of Radiation dose Evaluation using Monte Carlo Simulation while Treating Extrahepatic Bile Duct Cancer with High Dose Rate Intraluminal Brachytherapy

간외 담도암 고선량률 관내근접방사선치료 시 몬테카를로 시뮬레이션을 통한 주변장기의 선량평가 연구

  • Received : 2013.12.20
  • Accepted : 2014.01.22
  • Published : 2014.02.28


The relative dose calculated by MCNPX and the relative dose measured by ionization chamber and solid phantoms evaluated the accuracy comparing with Monte Carlo simulation. In order to apply Monte Carlo simulation the intraluminal brachytherapy of extrahepatic bile duct cancer, 192Ir sealed radioactive source replicate, Bile duct and surrounding organs were made using KMIRD phantom based on a South Korea standard man. To check the absorbed dose of normal organs around bile duct, we set the specific effective energy and initial radioactivity to 1 Ci using MCNPX. Evaluation of the accuracy of the Monte Carlo simulation, the difference of the relative dose is the most 1.96% that satisfy the criteria that is the relative error less than 2% suggested by MCNPX code. In addition, The specific effective energy and absorbed dose of normal organs that were relatively adjacent to bile duct such as right side of kidney, liver, pancreas, transverse colon, spinal cord, stomach and small intestine were relatively high. on the contrary, the organs that were relatively distant to bile duct such as left side of kidney, spleen, ascending colon, descending colon and sigmoid colon were relatively low.


MCNPX;Intraluminal Brachytherapy;KMIRD Phantom;Specific Effective Energy;Absorbed Dose


  1. K. B. Bae, T. H. Kim, Y. K. Choi, and N. W. Paik, "Surgical treatment and prognosis for 268 patients with biliary tract cancers," J. of Korean Surgical Society, Vol.58, No.3, pp.412-419, 2000.
  2. B. D. Cho, H. K. Oh, M. K. Jang, T. Y. Kyong, J. M. Lee, Y. B. Kim, H. Y. Kim, C. K. Park, and J. Y. Yoo, "Clinical characteristics and prognosis of the extrahepatic bile duct cancer," Korean J. of Gastroenterology, Vol.28, No.2, pp.251-259, 1996.
  3. Y. Sakamoto, T. Kosuge, K. Shimada, T. Sano, H. Ojima, J. Yamamoto, S. Yamasaki, T. Takayama, and M. Makuuchi, "Prognostic factors of surgical resection in middle and distal bile duct cancer: an analysis of 55 patients concerning the significance of ductal and radial margins," Surgery, Vol.137, No.4, pp.396-402, 2005.
  4. R. Sasaki, M. Takahashi, O. Funato, H. Nitta, M. Murakami, H. Kawamura, T. Suto, S. Kanno, and K. Saito, "Prognostic significance of lymph node involvement in middle and distal bile duct cancer," Surgery, Vol.129, No.6, pp.677-683, 2001.
  5. K. A. Vallis, I. S. Benjamin, A. J. Munro, A. Adam, C. S. Foster, R. C. N. Williamson, G. R. Kerr, and P. Price, "External beam and intraluminal radiotherapy for locally advanced bile duct cancer: Role and tolerability," Radiotherapy and Oncology, Vol.41, No.1, pp.61-66, 1996.
  6. H. S. Shin, J. S. Seong, W. C. Kim, H. S. Lee, S. R. Moon, I. J. Lee, K. K. Lee, K. R. Park, C. O. Suh, and G. E. Kim, "Combination of external beam irradiation and high-dose-rate intraluminal brachytherapy for inoperable carcinoma of the extrahepatic bile ducts," International J. of Radiation Oncology, Biology, Physics, Vol.57, No.1, pp.105-112, 2003.
  7. International Commission on Radiological Protection, 1996 Conversion Coefficients for use in Radiological Protection against External Radiation, ICRP Publication 74, Pergamon Press, 1996.
  8. P. B. Zanzonico, "Internal Radionuclide Radiation Dosimetry: A Review of Basic Concepts and Recent Developments," J. of Nuclear Medicine, Vol.41, No.2, pp.297-308, 2000.
  9. R. Loevinger, T. F. Budinger, and E. E. Waston, MIRD Primer for Absorbed Dose Calculations (revised), The Society of Nuclear Medicine, New York, 1991.
  10. P. E. Metcalfe, T. Kron, and P. Hoban, The Physics of Radiotherapy X-Rays from Linear Accelerators, Medical Physics Publishing, Madison, Wisconsin, 1997.
  11. B. Denise and Pelowitz(editor), $MCNPX^{TM}$ user's manual, version 2.6.0, Los Alamos National Laboratory, LA-CP-07-1473, 2008. Vol.3, No.2, pp.27-38, 2003.
  12. 이재기, 이춘식, 김현기, 박상현, 홍종호, 고광옥, 장한기, 장기원, 정제호, 안길훈, 신은혁, 인영기, 김종순, 김은실, 장윤균, 정규환, 진영우, 이진, 이연주, 성숙희, 김혁민, 오지민, 윤충현, 방사선 안전규제 기술 개발, 방사선방 호를 위한 표준한국인 설정연구, iTRS/TR-20047-01, 한양대학교, 과학기술부, 2004.
  13. 강세권, 정광호, 주라형, 조병철, 오도훈, 김수산, 김경주, 배훈식, 한영이, 신은혁, 박성호, 임천일, "제작된 선량 검증용 IMRT 팬텀의 몬테칼로 시뮬레이션: 예비적 연구", 의학물리학회논문지, 제18권, 제3호, 2007.
  14. T Takada, M Miyazaki, S Miyakawa, K Tsukada, M Nagino, S Kondo, J Furuse, H Saito, T Tsuyuguchi, F Kimura, H Yoshitomi, S Nozawa, M Yoshida, K Wada, H Amano, and F Miura, "Purpose, use, and preparation of clinical practice guidelines for the management of biliary tract and ampullary carcinomas," J. of Hepatobiliary Pancreatic Surgery, Vol.15, No.1, pp.2-6, 2008.
  15. J. Klempnauer, G. J. Ridder, M. Werner, A. Weimann, and R. Pichlmayr, "What constitutes long term survival after surgery for hilar cholangiocarcinoma?," Cancer, Vol.79, No.1, pp.26-34, 1997.<26::AID-CNCR5>3.0.CO;2-K
  16. H. Kurosaki, K. Karasawa, T. Kaizu, T. Matsuda, A. Okamoto, T. Sato, T. Ebara, and T. Tanaka, "Intraoperative radiotherapy for resectable extrahepatic bile duct cancer," International J. of Radiation Oncology, Biology, Physics, Vol.45, No.3, pp.635-638, 1999.
  17. H. Ishii, J. Furuse, M. Nagase, M. Kawashima, H. Ikeda, and M. Yoshino, "Relief of jaundice by external beam radiotherapy and intraluminal brachytherapy in patients with extrahepatic cholangiocarcinoma: results without stenting,"Hepatogastroenterology, Vol.51, No.58, pp.954-957, 2004.
  18. R Golfieri, E Giampalma, M Renzulli, A Galuppi, L Vicenzi, M. C. Galaverni, and A Cappelli, "Unresectable hilar cholangiocarcinoma: multimodality approach with percutaneous treatment associated with radiotherapy and chemotherapy," In Vivo, Vol.20, No.6A, pp.757-760, 2006.
  19. P. Andero, "Monte Carlo technique in medical radiation physics," Physics in Medicine and Biology, Vol.36, No.7, pp.861-920, 1991.
  20. 김상태, "영.유아의 입사피부선량 측정을 위한 몬테카를로 시뮬레이션", 한국콘텐츠학회논문지, 제12권, 제6호, 2012.