DOI QR코드

DOI QR Code

Preoperative administration effect of metronidazole, ceftriaxone sodium and their combination on stenotic index of jejunal anastomotic segment of dogs

  • Received : 2013.05.17
  • Accepted : 2014.02.05
  • Published : 2014.03.31

Abstract

The jejunum is the longest part of the small intestine and its lumen is mainly involved in the absorption of the nutrients. The present study was conducted to evaluate the effects of metronidazole, ceftriaxoine sodium and their combination on the stenotic index of the end to end jujunal anastomotic site. To accomplish this, 20 healthy stray dogs were subjected to end to end jejunal ansastmosis. Dogs in Group A (control) underwent jejunal anstomosis with no antibiotic prophylaxis, while those in Group B received surgery and metronidazole alone at 50 mg/kg, those in Group C received ceftriaxone sodium intravenously at 30 mg/kg body weight prior to surgery and dogs in Group D were given metronidazole in combination with ceftriaxone sodium at 50 mg/kg and 30 mg/kg, respectively, 2 h before surgical intervention. No significant difference (p > 0.05) in the stenotic index was observed at 14 days after jejunal anastomosis. These findings indicate that prophylactic administration of metronidazole and ceftriaxone sodium alone or in combination had no significant effect on the stenotic index of the jejunum.

References

  1. Athar M, Chaudhry NI, Shakoor A, Khan MA. Studies on end-to-end colonic anastomosis in the dog: a comparison of techniques. Acta Vet Hung 1996, 44, 349-356.
  2. Brown CD. Small intestines. In: Slatter DH (ed.). Textbook of Small Animal Surgery. 3rd ed. pp. 644-664, WB Saunders, Philadelphia, 2003.
  3. Ventura Cerda JM, Alos Alminana M, Nomdedeu Guinot J, Merino Sanjuan V, Salvador Sanchis JL. The pharmacokinetics of metronidazole and gentamicin in a single preoperative dose as antibiotic prophylaxis in colorectal surgery. Farm Hosp 2008, 32, 77-82. https://doi.org/10.1016/S1130-6343(08)72818-6
  4. Cleary RK, Grossmann R, Fernandez FB, Stull TS, Fowler JJ, Walters MR, Lampman RM. Metronidazole may inhibit intestinal colonization with Clostridium difficile. Dis Colon Rectum 1998, 41, 464-467. https://doi.org/10.1007/BF02235760
  5. Dilawar MS, Khan MA, ul Abidin Z, Azeem S, Majeed KA, Shahbaz A, Khan AR. Effect of variable degrees of jejuna resection upon different clinico-biochemical parameters in dogs. Korean J Vet Res 2011, 51, 309-313.
  6. Fossum TW. Surgery of the digestive system. In: Fossum TW, Duprey LP, O'Conner D (eds.). Small Animal Surgery. 3rd ed. pp. 369-414, Mosby, St.Louis, 2007.
  7. Gregory S. Gastric outflow tract disease. Lecture in small animal surgery. pp. 23-35, Royal Vet College, London, 2003.
  8. Goligher JC, Lee PW, Simpkins KC, Lintott DJ. A controlled comparison of one- and two-layer techniques of suture for high and low colorectal anastomoses. Br J Surg 1977, 64, 609-614. https://doi.org/10.1002/bjs.1800640902
  9. Hayashi MS, Wilson SE. Is there a current role for preoperative non-absorbable oral antimicrobial agents for prophylaxis of infection after colorectal surgery? Surg Infect 2009, 10, 285-288. https://doi.org/10.1089/sur.2008.9958
  10. Hinchey EJ, Richards GK, Prentis J. Metronidazole as prophylactic agent in wound infection after colon surgery. Surgery 1983, 93, 197-200.
  11. Holt DE. Large intestines. In: Slatter DH (ed.). Textbook of Small Animal Surgery. 3rd ed. pp. 665-682, WB Saunders, Philadelphia, 2003.
  12. Jain NC. Schalm's Veterinary Hematoiogy. Wiley, Philadelphia, 1986.
  13. Khan MA, Chaudry NI, Aziz T. An experimental study of end-to-end intestinal anastomosis in dogs. Pak Vet J 1988, 8, 124-128.
  14. de Lalla F. Antimicrobial prophylaxis in colorectal surgery: focus on ertapenem. Ther Clin Risk Manag 2009, 5, 829-839.
  15. Lewis RT. Advances in antibiotic prophylaxis in gastrointestinal surgery. Can Med Assoc J 1979, 121, 265-266.
  16. McAdams AJ, Meikle AG, Taylor JO. One layer or two layer colonic anastomoses? Am J Surg 1970, 120, 546-550. https://doi.org/10.1016/S0002-9610(70)80028-9
  17. Nichols RL, Choe EU, Weldon CB. Mechanical and antibacterial bowel preparation in colon and rectal surgery. Chemotherapy 2005, 51, 115-121. https://doi.org/10.1159/000081998
  18. Plumb DC. Veterinary drugs. In: Plumb's Veterinary Drug Handbook. 6th ed. Wiley-Blackwell, Ames, 2008.
  19. Ralphs SC, Jessen CR, Lipowitz AJ. Risk factors for leakage following intestinal anastomosis in dogs and cats: 115 cases (1991-2000). J Am Vet Med Assoc 2003, 223, 73-77. https://doi.org/10.2460/javma.2003.223.73
  20. Rasmussen L. Stomach. In: In: Slatter DH (ed.). Textbook of Small Animal Surgery. 3rd ed. pp. 618-634, WB Saunders, Philadelphia, 2003.
  21. Rau HG, Mittelkotter U, Zimmermann A, Lachmann A, Kohler L, Kullmann KH. Perioperative infection prophylaxis and risk factor impact in colon surgery. Chemotherapy 2000, 46, 353-363. https://doi.org/10.1159/000007309
  22. Ross D, Dijksman LM, Sondermeijer BM, Oudemansvan Straaten HM, de Wit LT, Gerhards MF. Perioperative selective decontamination of the digestive tract (SDD) in elective colorectal surgery. J Gastrointest Surg 2009, 13, 1839-1844. https://doi.org/10.1007/s11605-009-0970-z
  23. Song F, Glenny AM. Antimicrobial prophylaxis in colorectal surgery: a systematic review of randomized control trails. Br J Surg 1998, 85, 1232-1241. https://doi.org/10.1046/j.1365-2168.1998.00883.x
  24. Steel RGD, Torrie JH, Dickey DA. Principles and Procedures of Statistics: A Biometrical Approach. 3rd ed. McGraw-Hill, New York, 1997.
  25. Tavakoli A, Bakhtiari J, Khalaj A. Clinical evaluation of two suture pattern techniques in laparoscopic gastrojejunostomy in dog. Iran J Vet Surg 2007, 2, 39-46.
  26. Tobias KM, Ayres R. Key gastrointestinal surgeries: Intestinal anstomosis. Vet Med 2006, 226-229.
  27. Wang XC, Gui CQ, Zheng QS. Combined therapy of allantoin, metronidazole, dexamethasone on the prevention of intra-abdominal adhesion in dogs and its quantitative analysis. World J Gastroenterol 2003, 9, 568-571. https://doi.org/10.3748/wjg.v9.i3.568
  28. Weisman DL, Smeak DD, Birchard SJ, Zweigart SL. Comparison of a continuous suture pattern with a simple interrupted pattern for enteric closure in dogs and cats: 83 cases (1991-1997). J Am Vet Med Assoc 1999, 214, 1507-1510.
  29. Woodfield JC, Van Rij AM, Pettigrew RA, van der Linden AJ, Solomon C, Bolt D. A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery. Am J Surg 2003, 185, 45-49. https://doi.org/10.1016/S0002-9610(02)01125-X