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Analgesic Effects of Toad Cake and Toad-cake-containing Herbal Drugs -Analgesic effects of toad cake-

  • Inoue, Eiji (Tokyo Research Center, Kyushin Pharmaceutical Co., Ltd.) ;
  • Shimizu, Yasuharu (Tokyo Research Center, Kyushin Pharmaceutical Co., Ltd.) ;
  • Masui, Ryo (Tokyo Research Center, Kyushin Pharmaceutical Co., Ltd.) ;
  • Usui, Tomomi (Tokyo Research Center, Kyushin Pharmaceutical Co., Ltd.) ;
  • Sudoh, Keiichi (Tokyo Research Center, Kyushin Pharmaceutical Co., Ltd.)
  • Received : 2013.10.22
  • Accepted : 2014.02.12
  • Published : 2014.03.31

Abstract

Objectives: This study was conducted to clarify the analgesic effect of toad cake and toad-cake-containing herbal drugs. Methods: We counted the writhing response of mice after the intraperitoneal administration of acetic acid as a nociceptive pain model and the withdrawal response after the plantar surface stimulation of the hind paw induced by partial sciatic nerve ligation of the mice as a neuropathic pain model to investigate the analgesic effect of toad cake and toad-cake-containing herbal drugs. A co-treatment study with serotonin biosynthesis inhibitory drug 4-chloro-DL-phenylalanine methyl ester hydrochloride (PCPA), the catecholamine biosynthesis inhibitory drug ${\alpha}$-methyl-DL-tyrosine methyl ester hydrochloride (AMPT) or the opioid receptor antagonist naloxone hydrochloride was also conducted. Results: Analgesic effects in a mouse model of nociceptive pain and neuropathic pain were shown by oral administration of toad cake and toad-cake-containing herbal drugs. The effects of toad cake and toad-cake-containing herbal drugs disappeared upon co-treatment with PCPA, but not with AMPT or naloxone in the nociceptive pain model; the analgesic effect of toad-cake-containing herbal drugs also disappeared upon co-treatment with PCPA in the neuropathic pain model. Conclusion: Toad cake and toad-cake-containing herbal drugs have potential for the treatments of nociceptive pain and of neuropathic pain, such as post-herpetic neuralgia, trigeminal neuralgia, diabetic neuralgia, and postoperative or posttraumatic pain, by activation of the central serotonin nervous system.

Acknowledgement

Supported by : Kyushin Pharmaceutical Co., Ltd.

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