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Effects of Unripe Rubus coreanus Miquel Extract on Improvement of Lipid Metabolism in C57BL/6 Mice Fed a High-Cholesterol Diet

미숙과 복분자 열매 추출물이 고콜레스테롤 식이를 섭취시킨 C57BL/6 Mice의 지질대사 개선 효과

  • Jung, Myung-A (Jeonnam Bioindustry Foundation, Institute of Natural Resources Research (JINR)) ;
  • Cho, Sook-Hyun (Jeonnam Bioindustry Foundation, Institute of Natural Resources Research (JINR)) ;
  • Lee, Sun Young (Jeonnam Bioindustry Foundation, Institute of Natural Resources Research (JINR)) ;
  • Kim, Ji Hye (Jeonnam Bioindustry Foundation, Institute of Natural Resources Research (JINR)) ;
  • Oh, Kyonyeo (Jeonnam Bioindustry Foundation, Institute of Natural Resources Research (JINR)) ;
  • Kim, Young-Suk (Jeonnam Bioindustry Foundation, Institute of Natural Resources Research (JINR)) ;
  • Yoo, GooSang (Jeonnam Bioindustry Foundation, Institute of Natural Resources Research (JINR)) ;
  • Lee, Dong-Wook (Jeonnam Bioindustry Foundation, Institute of Natural Resources Research (JINR)) ;
  • Kim, Sunoh (Jeonnam Bioindustry Foundation, Institute of Natural Resources Research (JINR))
  • 정명아 (전남생물산업진흥원 천연자원연구원) ;
  • 조숙현 (전남생물산업진흥원 천연자원연구원) ;
  • 이선영 (전남생물산업진흥원 천연자원연구원) ;
  • 김지혜 (전남생물산업진흥원 천연자원연구원) ;
  • 오교녀 (전남생물산업진흥원 천연자원연구원) ;
  • 김영숙 (전남생물산업진흥원 천연자원연구원) ;
  • 유구상 (전남생물산업진흥원 천연자원연구원) ;
  • 이동욱 (전남생물산업진흥원 천연자원연구원) ;
  • 김선오 (전남생물산업진흥원 천연자원연구원)
  • Received : 2013.12.26
  • Accepted : 2014.04.22
  • Published : 2014.05.31

Abstract

Hypercholesterolemia is the presence of high levels of cholesterol in the blood, and it is regarded as a risk factor for cardiovascular disease due to the effects of cholesterol. The objective of this study was to investigate the effects of unripe Rubus coreanus Miquel (uRC) extract on lipid metabolism in hypercholesterolemic mice fed a high cholesterol diet (HC). uRC 50 (unripe R. coreanus 5% ethanol extract 50 mg/kg/day), uRC 100 (unripe R. coreanus 5% ethanol extract 100 mg/kg/day), uRC 300 (unripe R. coreanus 5% ethanol extract 300 mg/kg/day), and BO (borage seed oil containing minimum of 20% ${\gamma}$-linolenic acid 30 mg/kg/day) were orally administered for 60 days after HC. Oral administration of uRC 50, uRC 100, uRC 300, and BO significantly reduced serum total-cholesterol, triglyceride, LDL-cholesterol, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, atherogenic index, and cardiac risk factor levels. Similarly, uRC treatment elevated serum HDL-cholesterol levels. These results suggest that unripe R. coreanus extract could be established as a functional food for the improvement of lipid metabolism.

Acknowledgement

Supported by : 농촌진흥청

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