Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue

  • Cho, Moon Kyun (Department of Dermatology, Soonchunhyang University College of Medicine) ;
  • An, Je Min (Department of Dermatology, Soonchunhyang University College of Medicine) ;
  • Kim, Chul Han (Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine) ;
  • Kang, Sang Gue (Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine)
  • Received : 2013.05.30
  • Accepted : 2013.09.02
  • Published : 2014.01.15


Background Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue. Methods Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens. Results Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining. Conclusions Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.



Supported by : Soonchunhyang University


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