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Effects of Haw (Crataegus pinnatifida BUNGE) on Relaxation in the Lipid Components and Blood Glucose of Lipid Metabolism Syndrome

산사(Crataegus pinnatifida BUNGE)가 지질대사 증후군의 지질성분 및 혈당 완화에 미치는 영향

  • Received : 2014.02.10
  • Accepted : 2014.03.27
  • Published : 2014.06.30

Abstract

This study was designed in order to determine the influences of haw (Crataegus pinnatifida $B_{UNGE}$) on the lipid metabolism syndrome. Sprague Dawley rats, 7 weeks old, were given four different types of diets for 5 weeks: ND group (noncholesterolemic diet), HE group (non cholesterolemic diet+haw extract), CD group (cholesterolemic diet), CH group (cholesterolemic diet+haw extract). Concentrations of LDL-cholesterol, triglyceride, phospholipid, free cholesterol, cholesteryl ester, blood glucose were remarkably higher in the CD group than the other groups. But by treatment of haw extract group with cholesterolemic diet (CH group) were significantly decreased compared with CD group. Cholesteryl ester ratio was no difference between CD group and CH group. These results indicate that Crataegus pinnatifida $B_{UNGE}$ would be effective in lipid metabolism syndrome.

Keywords

Crataegus pinnatifida $B_{UNGE}$;Lipid component;Blood glucose;Lipid metabolism syndrome

References

  1. Lim, J. D., Yu, C. Y., Kim, M. J., Yun, S. J., Lee, S. J., Kim, N. Y., Chung, I. M., 2004, Comparison of SOD activity and phenolic compound contents in various Korean medicinal plants, Kor. J. Medicinal Crop. Sci., 12, 191-202.
  2. Wang, S. B., Ahn, E. M., Jung, J. W., 2009, The fruits of Crataegus pinnatifida Bunge ameliorates learning and memory impairments induced by scopolamine, Kor. J. Herbology, 24, 165-171.
  3. Yamakoshi, J., Kataoka, S., Koga, T., Ariga, T., 1999, Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in choles-terol-fed rabbits, Atherosclerosis, 142, 139-149. https://doi.org/10.1016/S0021-9150(98)00230-5
  4. Zhang, J., Liang, R., Wang, L., Yan, R., Hou, R., Gao, S., Yang, B., 2013, Effects of an aqueous extract of Crataegus pinnatifida Bge. var. major N.E.Br. fruit on experimental atherosclerosis in rats, J. Ethnopharmacology, 148, 563-569. https://doi.org/10.1016/j.jep.2013.04.053
  5. Kim, J. S., Lee, G. D., Kwon, J. H., Yoon, H. S., 1993, Identification of phenolic antioxidative components in Crataegus pinnatifida Bunge, J. Kor. Agric. Chem. Soc., 36, 154-157.
  6. Kwok, C. Y., Wong, C. N. Y., Yau, M. Y. C., Yu, P. H. F., Au, A. L. S., Poon, C. C. W., Seto, S. W., Lam, T. Y., Kwan, Y. W., Chan, S. W., 2010, Consumption of dried fruit of Crataegus pinnatifida (hawthorn) suppresses high-cholesterol diet- induced hypercholes- terolemia in rats, J. Functional Foods, 2, 179-186. https://doi.org/10.1016/j.jff.2010.04.006
  7. Liu, P., Yang, B., Kallio, H., 2010, Characterization of phenolic compounds in chinese hawthorn (Crataegus pinnatifida Bge. var. major) fruit by high performance liquid chromatography -lectrospray ionization mass spectrometry, Food Chemistry, 121, 1188-1197. https://doi.org/10.1016/j.foodchem.2010.02.002
  8. Matsubara, M., Maruoka, S., Katayose, S., 2002, Decreased plasma adiponectin con- centrations in women with dyslipidemia, J. Clinical Endocrinology & Metabolism, 87, 2764-2769. https://doi.org/10.1210/jcem.87.6.8550
  9. O'Keefe, J. H., Bell, D. S. H., 2007, Postprandial hyperglycemia/hyperlipidemia (post- prandial dysmetabolism) is a cardiovascular risk factor, Am. J. cardiology, 100, 899-904. https://doi.org/10.1016/j.amjcard.2007.03.107
  10. Park, C. S., Yang, K. M., Kim, M. L., 2006, Functional properties of medicinal plant extracts, Kor. J. food Cookery Sci., 23, 720-727.
  11. Park, S. J., Shin, E. H., Lee, J. H., 2012, Biological activities of solvent fractions from methanolic extract of Crataegi fructus, Kor. J. Food & Nutr., 25, 897-902. https://doi.org/10.9799/ksfan.2012.25.4.897
  12. Ryu, B. H., Koo, K. S., Baek, U. H., Bang, H. S., Hong, Y. J., Park, S. W., Lee, H. M., 2007, The effect of eight-weeks exercise therapy and diet therapy on male middle school students obesity and physical fitness, Kor. J. Growth and Development, 15, 87-93.
  13. Grundy, S. M., 1998, Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome, Am. J. cardiology, 81, 18-25.
  14. Chon, J. W., Park, J. K., Lee, M. A., Jeong, M. R., Han, J. H., Park, Y. K., 2009, Fermented Crataegi fructus vinegar improves lipid metabolism in rats fed high fat diet, J. Kor. Soc. Food Sci. Nutr., 38, 1024-1031. https://doi.org/10.3746/jkfn.2009.38.8.1024
  15. Chon, J. W., Park, S. J., Han, J. H., Park, S. H., 2005, Study of Crataegi fructus for medicinal foods applications -nutrition composition and scheme for foods-, Kor. J. Oriental Physiology & Pathology, 19, 1220-1224.
  16. Chung, S. T., Chung, D. C., Lee, B. K., 1997, Relative risk of hypertension for obesity, hypercholesterolemia and hypertriglyceridemia, Exercise Science, 6, 45-57.
  17. Heo, H. J., Nam, S. Y., Lee, S. K., Chung, S. J., Yoon, J. H., 2012, The relationship between high energy/low nutrient food consumption and obesity among Korean children and adolescents, Kor. J. Community Nutr., 17, 226-242. https://doi.org/10.5720/kjcn.2012.17.2.226
  18. Hong, S. I., Park, H. J., Kwak, S. J., Park, S. H., Yu, H. J., Won, D. J., Prak, J. S., Lee, D. J., Ahn, S. H., Koo, J. S., 1996, Comparison of atherosclerotic heart disease risks between vegetarian and non-vegetarian, Kor. J. Medicine, 51, 45-52.
  19. Hur, J. W., Jeon, Y. J., Park, S. K., 1985, Determination of total cholesterol, free cholesterol and individual cholesteryl esters in various liver diseases, Kor. J. Gastroenterology, 17, 129-135.
  20. Kim, H. S., 2006, Effects of the Saururus chinensis Baill hot-water extract intake on the lipid components and metabolic enzyme activities in hyperlipidemic rats, Kor. J. Exercise Nutr., 10, 99-106.
  21. Kim, H. S., Seong, J. H., 2008, Effects of chitosan oligosaccharide supplementation on blood glucose, lipid components and enzyme activities in hyperglycemic rats, Kor. J. Food & Nutr., 21, 328-335.