DOI QR코드

DOI QR Code

Cell Death of Human Promyelocytic Leukemia Cell after Low Dose of Electron Beam Irradiation with TNF-α

저 농도의 전자선을 조사한 전골수구성 백혈병 세포 죽음에서의 TNF-α 작용 효과

  • 김동현 (부산가톨릭대학교 방사선학과) ;
  • 고성진 (부산가톨릭대학교 방사선학과)
  • Received : 2014.05.07
  • Accepted : 2014.05.28
  • Published : 2014.06.28

Abstract

Acute promyelocytic leukemia (APL) is a cancer of the blood. Although electron beam (EB) irradiation is used with other anti-cancer agents, EB irradiation can be harmful to normal tissues around the cancer. In the present study, we evaluate the differential cytotoxic effect of EB irradiation with other molecules, including TNF-${\alpha}$, on DMSO-treated HL-60 cells and HL-60 cells. HL-60 cells are the human promyleocytic leukemia cell line and are differentiated by DMSO. DMSO-treated HL-60 cells are considered to be normal granulocytic cells. In these results, TNF-${\alpha}$ may be used as the potential agent for the treatment of blood cancer without side effects in low dose of EB irradiation therapy.

Keywords

HL-60 Cells;TNF-${\alpha}$;EB Irradiation;Apoptosis

Acknowledgement

Supported by : 부산가톨릭대학교

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