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Detection and Monitoring of Benzylpenicillin Residues in Livestock and Marine Products

유통 축·수산물 중 잔류벤질페니실린의 검출 및 모니터링

  • Lee, Hyo Jeong (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration) ;
  • Kang, Young Won (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration) ;
  • Lee, Soo Min (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration) ;
  • An, Kyung A (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration) ;
  • Lee, Ryun Kyung (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration) ;
  • Seo, Sang Cheol (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration) ;
  • Lee, Ju Hee (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration) ;
  • Im, Moo Hyeog (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration) ;
  • Lee, Jeong Rim (Hazardous Substances Analysis Division, Daegu Regional Korea Food & Drug Administration) ;
  • Hong, Choong Man (Medical Products Safety Division, Seoul Regional Korea Food & Drug Administration) ;
  • Chang, Moon Ik (Food Chemical Residues Division, National Institute of Food and Drug Safety Evaluation) ;
  • Cho, Yoon Jae (Food Chemical Residues Division, National Institute of Food and Drug Safety Evaluation)
  • 이효정 (대구지방식품의약품안전청 유해물질분석과) ;
  • 강영원 (대구지방식품의약품안전청 유해물질분석과) ;
  • 이수민 (대구지방식품의약품안전청 유해물질분석과) ;
  • 안경아 (대구지방식품의약품안전청 유해물질분석과) ;
  • 이륜경 (대구지방식품의약품안전청 유해물질분석과) ;
  • 서상철 (대구지방식품의약품안전청 유해물질분석과) ;
  • 이주희 (대구지방식품의약품안전청 유해물질분석과) ;
  • 임무혁 (대구지방식품의약품안전청 유해물질분석과) ;
  • 이정림 (대구지방식품의약품안전청 유해물질분석과) ;
  • 홍충만 (서울지방식품의약품안전청 의료제품안전과) ;
  • 장문익 (식품의약품안전처 식품의약품안전평가원 잔류물질과) ;
  • 조윤제 (식품의약품안전처 식품의약품안전평가원 잔류물질과)
  • Received : 2013.11.29
  • Accepted : 2014.03.17
  • Published : 2014.06.30

Abstract

Penicillin and its salts, including the benzatine, procaine, and sodium salts, have been widely used in human and veterinary medicine. Owing to their low toxicity, they currently form the most important group of antibiotics. However, overdose and abuse of these antibiotics may lead to potential risk in human health. Therefore, this study was conducted to validate the analysis method established by the Korea Food Code in 2012 and to monitor the levels of benzylpenicillin residues in products with reference to the maximum residue level (MRL). Of the 232 product samples tested, benzylpenicillin was detected in 11 livestock products and 2 marine products. Benzylpenicillin concentrations were found to be lower than the MRL in 12 products; however, the concentration of benzylpenicillin was found to be greater than the MRL in 1 pork product. The limit of quantification (LOQ) for benzylpenicillin was found to be 0.001-0.002 mg/kg, with an average recovery of 90.4-115.3%. Calibrations showed good linearity of 0.995 over a range of 0.002-0.05 mg/kg.

Keywords

benzylpenicillin;validation;monitoring;veterinary drug;MRLs

Acknowledgement

Supported by : 식품의약품안전청

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