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Anti-amnesic Effect of Eriobotrya japonica Leaf Extract on Scopolamine-induced Memory Impairment in Rats

Scopolamine으로 유도된 기억력 손상 동물모델에서 비파엽 추출물의 학습 및 기억력 개선 효과

  • Bae, Donghyuck (Jeollanamdo Institute of Natural Resources Research) ;
  • Kim, Jihye (Jeollanamdo Institute of Natural Resources Research) ;
  • Na, Ju-Ryun (Jeollanamdo Institute of Natural Resources Research) ;
  • Kim, Yujin (Jeollanamdo Institute of Natural Resources Research) ;
  • Lee, Joon-Yeol (Korea INS Pharm Research Institute) ;
  • Kim, Sunoh (Jeollanamdo Institute of Natural Resources Research)
  • 배동혁 (전라남도 천연자원연구원) ;
  • 김지혜 (전라남도 천연자원연구원) ;
  • 나주련 (전라남도 천연자원연구원) ;
  • 김유진 (전라남도 천연자원연구원) ;
  • 이준열 (한국인스팜(주) 중앙연구소) ;
  • 김선오 (전라남도 천연자원연구원)
  • Received : 2014.02.11
  • Accepted : 2014.02.28
  • Published : 2014.06.30

Abstract

The present study was conducted to evaluate the effects of extract from Eriobotrya japonica leaves (EJE) on cognitive impairment induced by scopolamine, a muscarinic antagonist, in rats. Scopolamine injection (1 mg/kg, i.p.) impaired performance in rats in the passive avoidance test as well as in water maze test and severely reduced cholinergic system reactivity, as indicated by reduced acetylcholine levels and increased acetylcholinesterase activity. Daily administration of EJE significantly increased step-through latency in the passive avoidance test, reduced escape latency, and increased time spent in the platform quadrant in the Morris water maze test. EJE protected against scopolamine-induced cholinergic system deficit, including reduced acetylcholine levels and increased acetylcholinesterase activity in whole brain homogenates. These results suggest that EJE provides a significant anti-amnesic effect against scopolamine-induced cholinergic system deficits and cognitive impairment.

Acknowledgement

Supported by : 한국산업기술진흥원

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