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Neuroprotective Effects of Bread Containing Cirsium setidens or Aster scaber

곤드레 또는 참취를 함유한 빵의 뇌신경 보호효과

  • Kwon, Ki Han (Dept. of Food Science & Nutrition, Gwangju University) ;
  • Lim, Heekyung (Dept. of Food Science & Nutrition, Gwangju University) ;
  • Chung, Mi Ja (Dept. of Food Science & Nutrition, Gwangju University)
  • 권기한 (광주대학교 식품영양학과) ;
  • 임희경 (광주대학교 식품영양학과) ;
  • 정미자 (광주대학교 식품영양학과)
  • Received : 2014.02.05
  • Accepted : 2014.03.17
  • Published : 2014.06.30

Abstract

This study investigated the neuroprotective effects of bread containing extract from Cirsium setidens (CS) or Aster scaber (AS) against $H_2O_2$-induced death of human brain neuroblastoma SK-N-SH cells. Treatment with bread containing extract from CS (CSB) or AS (ASB) reduced $H_2O_2$ cytotoxicity in SK-N-SH cells, the intracellular ROS level, and the phospho-p38 mitogen-activated protein kinase (MAPK) level. In the sensory evaluation, wild vegetable flavor scores of CSB were higher than those of ASB and bread containing 0% CS or AS (NB). In terms of appearance, color, flavor, softness, and overall acceptability, CSB and ASB showed higher scores than NB, but no differences were observed between CSB and ASB. These results indicate that CSB and ASB have potent health benefits in terms of neuroprotection against oxidative stress mediated through antioxidant activity and inhibition of p38 phosphorylation in brain neural cells. Thus, CS and AS could be considered as a health functional material.

Acknowledgement

Supported by : 한국연구재단

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