Kaposi's Varicelliform Eruption in Atopic Dermatitis treated with Korean medicine

  • Lee, Dong-Jin (Department of Ophthalmology, Otolaryngology and Dermatology, Korean Medicine Hospital, Pusan National University) ;
  • Kwon, Kang (Department of Ophthalmology, Otolaryngology and Dermatology, Korean Medicine Hospital, Pusan National University) ;
  • Sun, Seung-Ho (Department of Internal Medicine, Korean Medicine Hospital, Sangji University) ;
  • Seo, Hyung-Sik (Department of Ophthalmology, Otolaryngology and Dermatology, Korean Medicine Hospital, Pusan National University)
  • Received : 2014.01.18
  • Accepted : 2014.02.12
  • Published : 2014.06.30


Objectives: This case report is to present a complete recovery from Kaposi's varicelliform eruption (KVE) that occurred in a patient with atopic dermatitis by applying Korean Medicine therapies. Methods: Hwangyeonhaedoktang pharmacopuncture (HP), 0.3 mL, and 25% bee venom pharmacopuncture (BVP), 0.1 mL, were injected, 0.2 mL each, at both BL13 acupoints once a day in the morning. Acupuncture was applied at Sama Upper, Middle and Lower of the Master Tung acupuncture points and at ST44 on the left lateral for 30 minutes twice a day. The affected face was gauze dressed with mixture of 2.0 mL HP and 1.0 mL 25% BVP with 20 mL of normal saline twice a day. Herbal Medicine, Seungmagalgeuntang, was administered three times a day after each meal. Results: Rashes and papules on the face were completely cleared after 10 days of treatments. Conclusion: KVE, an acute and urgent dermatitis, can be effectively treated with Korean medicine.


Supported by : Pusan National University Hospital


  1. Lubbe J, Sanchez-Politta S, Tschanz C, Saurat JH. Adults with atopic dermatitis and herpes simplex and topical therapy with tacrolimus: what kind of prevention? Arch Dermatol. 2003;139(5):670-1.
  2. Hood JL, Jallouk AP, Campbell N, Ratner L, Wickline SA. Cytolytic nanoparticles attenuate HIV-1 infectivity. Antivir Ther. 2013;18(1):95-103.
  3. Li L, Zeng H, Shan L, Yuan X, Li Y, Liu R, et al. The different inhibitory effects of Huang-Lian-Jie-Du-Tang on cyclooxygenase 2 and 5-lipoxygenase. J Ethnopharmacol. 2012;143(2):732-9.
  4. Zeng H, Liu X, Dou S, Xu W, Li N, Liu X, et al. Huang-Lian-Jie-Du-Tang exerts anti-inflammatory effects in rats through inhibition of nitric oxide production and eicosanoid biosynthesis via the lipoxygenase pathway. J Pharm Pharmacol. 2009;61(12):1699-707.
  5. Hwang DY. [Bangyakhappyeon]. Seoul: Younglimsa; 2007. p. 195-6. Korean.
  6. Choi MH. [Master Tung's acupuncture & moxibustion]. 2nd ed. Seoul: Iljungsa; 2005. Chapter 08, Eight-eight region; p.134-5. Korean.
  7. Textbook committee of the Korean acupuncture & moxibustion society. [Acupuncture & moxibustion (vol. 2)]. 2nd ed. Gyunggi: Jipmoondang; 2008. Chapter 01, Head & Face; p. 5. Korean.
  8. Rystedt I, Strannegard IL, Strannegard O. Recurrent viral infections in patients with past or present atopic dermatitis. Br J Dermatol. 1986;114(5):575-82.
  9. Raychaudhuri SP, Raychaudhuri SK. Revisit to Kaposi's varicelliform eruption: role of IL-4. Int J Dermatol. 1995;34(12):854-6.
  10. Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H. Interleukin-18 regulates both Th1 and Th2 response. Annu Rev Immunol. 2001;19:423-74.
  11. Amatsu A, Yoshida M. Detection of herpes simplex virus DNA in non-herpetic areas of patients with eczema herpeticum. Dermatology. 2000;200(2):104-7.
  12. Sterling JC. Virus infection. In: Burns T, Breathnach S, Cox N, Griffiths C. Rook's textbook of dermatology. 7th ed. Massachusetts: Blackwell; 2004. p. 2535-8.
  13. Osawa K, Etoh T, Ariyoshi N, Ishii I, Ohtani M, Kariya S, et al. Relationship between Kaposi's varicelliform eruption in Japanese patients with atopic dermatitis treated with tacrolimus ointment and genetic polymorphisms in the IL-18 gene promoter region. J Dermatol. 2007;34(8):531-6.
  14. Stroud GM. Recurrent herpes simplex and steroid dosage-In a patient with the nephrotic syndrome due to primary systemic amyloidosis. Arch Dermatol. 1961;84(3):396-401.
  15. Kim HB, Cho YJ, Yoo KH, Kim DY, Kim JH, Kim HJ, et al. [Survey on the management of atopic dermatitis]. Kor J Asthma Allergy Clin Immunol. 2012;32(1):16-20. Korean.
  16. Falco A, Barrajon-Catalan E, Menendez-Gutierrez MP, Coll J, Micol V, Estepa A. Melittin-loaded immunoliposomes against viral surface proteins, a new approach to antiviral therapy. Antiviral Res. 2013;97(2):218-21.
  17. Hasegawa K, Obermeyer Z, Milne LW. Eczema herpeticum. J Emerg Med. 2012;43(5):341-2.
  18. Ambo M. Relapsing Kaposi's varicelliform eruption and herpes simplex following facial tacrolimus treatment for atopic dermatitis. Acta Derm Venereol. 2002;82(3):224-5.
  19. Chin HW, Jang HS, Jang BS, Jo JH, Kim MB, Oh CK, et al. [A study on utilization of alternative medicine for patients with atopic dermatitis]. Korean J Dermatol. 2005;43(7):903-11. Korean.
  20. Cavalie M, Giacchero D, Cardot-Leccia N, Passeron T, Lacour JP. Kaposi's varicelliform eruption in a patient with pityriasis rubra pilaris (pityriasis rubra pilaris herpeticum). J Eur Acad Dermatol Venereol. 2013;27(12):1585-6.
  21. Dekio I, Chinuki Y, Furumura M, Morita E. Recurrent Kaposi's varicelliform eruption successfully controlled by low-dose oral valaciclovir. J Dermatol. 2012;39(2):197-9.
  22. Barton RL, Brunsting LA. Kaposi's varicelliform eruption: review of the literature and report of two cases of its occurrence in adults. Arch Dermatol Syphilol. 1944;50:99.
  23. Lynch FW, Steves RJ. Kaposi's varicelliform eruption. Arch Dermatol Syphilol. 1947;55(3):327-36.
  24. Goodyear HM, Davies JA, Mcleish P, Buchan A, Skinner GRB, Winther M, et al. Growth of herpes simplex type 1 on skin explants of atopic eczema. Clin Exp Dermatol. 1996;21(3):185-9.

Cited by

  1. Twenty-two Case of Acne Treated by Hwangryunhaedok-tang Pharmacopuncture Therapy Combined with Herbal Medicine and Extrusion vol.28, pp.3, 2015,