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Analytical Study on Medical Leech in the Last 10 Years: A Suggestion of Practical Use on Obesity and Metabolic Syndrome

최근 10년간의 수질(水蛭) 연구 동향: 비만 및 대사증후군에의 응용 가능성 제고

  • Lee, Jin-Won (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Sangji University) ;
  • Park, Won-Hyung (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Sangji University) ;
  • Cha, Yun-Yeop (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Sangji University) ;
  • Song, Yun-Kyung (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Ga-Chon University)
  • 이진원 (상지대학교 한의과대학 한방재활의학교실) ;
  • 박원형 (상지대학교 한의과대학 한방재활의학교실) ;
  • 차윤엽 (상지대학교 한의과대학 한방재활의학교실) ;
  • 송윤경 (가천대학교 한의과대학 한방재활의학교실)
  • Received : 2014.05.20
  • Accepted : 2014.06.01
  • Published : 2014.06.30

Abstract

Objectives: The purpose of this study is to analyse research trends about medical leech in the last 10 years. Methods: We searched the papers with key words of 'medical leech', '水蛭' in China Knowledge Resource Integrated Database (CNKI), Korean traditional knowledge portal, DBPIA, KISS. We classified the papers by year and content. Results: 1. Result of the classification on the basis of the research methods, 50 studies are clinical case reports, 301 studies are experimental paper, 599 studies are clinical trial study, 219 studies are literature review. 2. Result of the classification on the basis of the research topics, 454 studies are the effect of anticoagulant research, 84 studies are diabetes and renal disease research, 194 studies are pharmacological properties research, and 43 studies are effect of allergic and anti-inflammatory research. 3. The proportion of the coagulation effect study tends to decrease every year since 2006. 4. Leech research tends to decrease in last 3 years. 5. Recently, there are many research in psychiatry, orthopedic diseases and beauty. 6. There are 10 studies related to leech in Korean. Conclusions: The researches of medical leech are actively done. The diversity of subjects is getting wider and richer.

Acknowledgement

Supported by : 보건복지부

References

  1. Kim C, Shin M, Ahn D, Lee K. Dictionary of Chinese medicine II. Seoul : Jeoungdamsa. 1997 : 2565-8.
  2. Liu X, Yang Y, Wu L. Study medical leech and chemical composition of pharmacognosy progress and prospects. J Glob Chin Med. 2012 ; 8(5) : 637-40.
  3. Corral-Rodríguez MA, Macedo-Ribeiro S, Pereira PJ, Fuentes- Prior P. Leech-derived thrombin inhibitors: from structures to mechanisms to clinical applications. J Med Chem. 2010 ; 53(10) : 3847-61. https://doi.org/10.1021/jm901743x
  4. Zhong S, Yang D, Cui Z. Studies on anticoagulant constituents in dried Whitmania pigra. China J Chin Mater Med. 2008 ; 23(1) : 12-5.
  5. MedilinePlus. MEDLINE [Internet], Bethesda (MD): U.S. National Library of Medicine; 2013 [cited 2013 Sep 30]. Available from: http://www.nlm.nih.gov/medlineplus/.
  6. China Knowledge Resource Integrated Database (CNKI) [Internet]. China: CNKI; 2013 [cited 2013 Sep 30]. Available from: http://www.cnki.com.
  7. Nurimedia. DBPIA [Internet]. Seoul: Nurimedia; 2013 [cited 2013 Sep 30]. Available from: http://www.dbpia.co.kr.
  8. Korean Studies Information. KISS [Internet]. Paju: Korean Studies Information; 2013 [cited 2013 Sep 30]. Available from: http://kiss.kstudy.com.
  9. Korean Intellectual Property Office. Korean Traditional Knowledge Portal [Internet]. Daejeon: Patent Office; 2013 [cited 2013 Sep 30]. Available from: http://www.koreantk.com.
  10. Jianfu Z. Endoscopic nasal leech removed 30 cases. J Clin Otorhinolaryngol Head Neck Surg. 2010 ; 17(1) : 23-8.
  11. Yongli L, Hongxia L. Jiweiling capsule treatment of multiple sclerosis 52 cases. Shaanxi Tradit Chin Med. 2005 ; 26(3) : 222-4.
  12. Hua L. Nasal leech cause epistaxis report of 16 cases. Chin J Surg. 2006 ; 12(2) : 100-1.
  13. Hong Z, Xiang Zi X, Hui S. Shu Governor drink treatment of ankylosing spondylitis 40 patients. J New Chin Med. 2008 ; 40(10) : 34-5.
  14. Chen F, Yi H. Medical leech treatment for 31 cases of knee osteoarthritis efficacy. J Chin Med Front. 2010 ; 22(5) : 50-1.
  15. Haixia B, Li J. Naotaitong particles to treat epilepsy 38 cases. Shaanxi Tradit Chin Med. 2012 ; 33(10) : 1292-3.
  16. Ha T. Effects of Tong Xin Lou (TXL) on levels of serum lipid in high fat diet-induced dyslipidemia in mice. Korea J Herbol. 2012 ; 27(3) : 107-12.
  17. Seo S. The effects of Hirudo on streptozotocin-induced diabetic nephropathic rats. J Korean Orient Med. 2008 ; 29(4) : 133-45.
  18. Kim D. The effects of Hwalhyulmaksung-bang (Huoxiemoxingfang) on membranous nephropathy induced by cationic bovine serum albumin in mouse model. J Korean Orient Med. 2008 ; 29(4) : 68-82.
  19. Lee J. The effects of Ssanggang-tang on rat with induced hyperlipidemia. Korean J Orient Intern Med. 2008 ; 29(2) : 432-42.
  20. Lee J. Effect of Whitmania pigra whitman on the allergic inflammatory response. Korean J Orient Med. 2008 ; 29(2) : 81-95.
  21. Suk JW. The effect of Hirudin herbal-acupuncture on neurotransmitters against middle cerebral artery occlusion (MCAO) rats. J Korean Inst Herbal-Acupunct. 2004 ; 7(2) : 29-41.
  22. Bae KY. Vasodilatory activities and safety of the water extracts of three medicinal remedy in species of insects. J Orient Obstet Gynecol. 2007 ; 20(1) : 114-24.
  23. Jung HJ. A study the effects of three preparations of Hirudo on the expression of pro-inflammatory cytokines in human bronchial epithelial cells line BEAS-2B. J Korean Orient Intern Med. 2004 ; 25(4) : 260-73.
  24. Kim J. Review of natural materials in diabetic peripheral neuropathy. Korean J Orient Med Physiol Pathol. 2011 ; 25(6) : 1056-60.
  25. Choi WJ. Clinical study on a case of somatoform disorder with chronic pelycalgia and hemiparesis. J Orient Neuropsychiatry. 2004 ; 15(2) : 203-10.
  26. Union of College of Korean Traditional Medicine. Phytology (herbal medicine). Seoul : Yeonglimsa. 2004 : 473-4.
  27. Hildebrandt JP, Lemke S. Small bite, large impact-saliva and salivary molecules in the medicinal leech, Hirudo medicinalis. Die Naturwissenschaften [Naturwissenschaften]. 2011 ; 98(12) : 995-1008. https://doi.org/10.1007/s00114-011-0859-z
  28. Kejian L. Leech treatment of acute ischemic stroke systematic review of randomized controlled trials. Mod J Integr Tradit Chin West Med. 2006 ; 15(17) ; 13-5.
  29. Lee JY, Kim EK, Oh HA, Lee HS, Sohn Y, Jung HS, et al. Effect of Whitmania pigra whitman on the allergic inflammatory response. J Korean Orient Med. 2008 ; 29(2) : 81-95.
  30. Porshinsky BS, Saha S, Grossman MD, Beery PR, Stawicki SPA. Clinical uses of the medicinal leech: a practical review. J Postgrad Med. 2011 ; 57(1) : 61-73. https://doi.org/10.4103/0022-3859.74295
  31. Papavramidou N, Christopoulou-Aletra H. Medicinal use of leeches in the texts of ancient Greek, Roman and early Byzantine. Intern Med J. 2009 ; 39(1) : 624-7. https://doi.org/10.1111/j.1445-5994.2009.01965.x
  32. Hanif A, Nouri M, Amirjamshidi A. Medicinal leech therapy in neurosurgical practice. Congr Iran Neurosurg. 2012 ; 26(3) : 14-6.
  33. Whitaker IS, Oboumarzouk O, Rozen WM, Naderi N, Balasubramanian SP, Azzopardi EA, et al. The efficacy of medicinal leeches in plastic and reconstructive surgery: a systematic review of 277 reported clinical cases. Microsurgery. 2012 ; 32(3) : 240-50. https://doi.org/10.1002/micr.20971
  34. Chen F, Yi H. Since the proposed him for the medical treatment of 31 cases of knee osteoarthritis efficacy. J Chin Med Front. 2010 ; 22(5) : 50-1.
  35. Mao J, Wei Y. Type 2 diabetes clinical research Hypoglycemic capsules cellulite treatment. Guangming Chin Med. 2004 ; 19(3) : 13-4.
  36. Lepor NE, Vogel RE. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA. 2001 ; 285 : 2486-97. https://doi.org/10.1001/jama.285.19.2486