The Effects of Bambusae caulis in liquamen and Bambusae concretio silicae on Blood Sugar Reduction and Improvement of Peripheral Nerve Function in Diabetic Rats Induced with Streptozotocin

죽력(竹瀝)과 천축황(天竺黃)이 Streptozotocin으로 당뇨가 유발된 백서의 혈당강하 및 말초신경기능회복에 미치는 영향

  • Park, Soo-Gon (Chung Yeon Oriental Clinic) ;
  • Bae, Kil-Joon (Department of Oriental Rehabilitaion Medicine, College of Oriental Medicine, Dongshin University) ;
  • Lee, Ook-Jae (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Kim, Seon-Jong (Department of Oriental Rehabilitaion Medicine, College of Oriental Medicine, Dongshin University) ;
  • Jung, Min-Young (Department of Oriental Medical Ophthalmology, Otolaryngology & Dermatology, College of Oriental Medicine, Dongshin University)
  • 박수곤 (청연한의원) ;
  • 배길준 (동신대학교 한의과대학 한방재활의학과교실) ;
  • 이욱재 (동신대학교 한의과대학 침구의학교실) ;
  • 김선종 (동신대학교 한의과대학 한방재활의학과교실) ;
  • 정민영 (동신대학교 한의과대학 한방안이비인후피부과학교실)
  • Received : 2013.12.18
  • Accepted : 2014.01.03
  • Published : 2014.01.31

Abstract

Objectives This study was designed to investigate the effects of Bambusae caulis in liquamen and Bambusae concretio silicae on blood sugar reduction and improvement of peripheral nerve function in diabetic rat models. Methods Diabetic rat models induced by streptozotocin were divided into five groups. We fed experimental group I of rats basal diet and administered normal saline (3 ml, 1 time/1 day) for 6 weeks. We fed experimental group II of rats basal diet and administered Bambusae caulis in liquamen (100 mg/kg, 1 time/1 day) for 6 weeks. We fed experimental group III, IV, V of rats basal diet and administered Bambusae concretio silicae (100 mg/kg, 200 mg/kg, 400 mg/kg once a day) for 6 weeks. We investigated weight and glucose level of rats, and carried out touch test, hot plate test, sensory & motor nerve conduction velocity test and immunohistochemical study after 48 hours, 2 weeks, 4 weeks and 6 weeks. Results 1. The weight of all experimental group was gradually decreased. And glucose level was significantly decreased in the experimental group II, III, IV, V as compared with experimental group I. Especially experimental group II, IV, V were significantly decreased as compared with experimental group III. 2. In the quantitative analysis by touch test and hot plate test, mechanical pain threshold and heat pain threshold were significantly decreased in the other experimental groups as compared with experimental group I. Especially experimental group II, IV, V were significantly decreased as compared with experimental group III. 3. In the sensory and motor nerve conduction velocity test, sensory and motor nerve conduction velocity were significantly increased in the other experimental groups as compared with experimental group I. Especially experimental group II, IV, V were significantly increased as compared with experimental group III. 4. In the substance P immunohistochemical study, experimental group II, IV, V showed strong immune response in spinal cord. Conclusions Bambusae caulis in liquamen and Bambusae concretio silicae were probably useful to treat patients with diabetic peripheral neuropathy.

Keywords

Bambusae caulis in liquamen;Bambusae concretio silicae;Diabetic peripheral neuropathy;Peripheral nerve function

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