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Lead, Mercury and Cadmium Concentration in Blood and Related Factors among Korean Preschoolers

국내 3-7세 어린이의 혈중 납, 수은, 카드뮴 농도와 관련요인

  • Seo, Ju-Hee (Heavy Metal Exposure Environmental Health Center, Dong-A University) ;
  • Kim, Byoung-Gwon (Department of Preventive Medicine, College of Medicine, Dong-A University and Heavy Metal Exposure Environmental Health Center, Dong-A University) ;
  • Kim, Yu-Mi (Department of Preventive Medicine, College of Medicine, Dong-A University and Heavy Metal Exposure Environmental Health Center, Dong-A University) ;
  • Kim, Rock-Bum (Department of Preventive Medicine, College of Medicine, Dong-A University and Heavy Metal Exposure Environmental Health Center, Dong-A University) ;
  • Chung, Jin-Yong (Heavy Metal Exposure Environmental Health Center, Dong-A University) ;
  • Hong, Young-Seoub (Department of Preventive Medicine, College of Medicine, Dong-A University and Heavy Metal Exposure Environmental Health Center, Dong-A University)
  • 서주희 (동아대학교 중금속노출 환경보건센터) ;
  • 김병권 (동아대학교 의과대학 예방의학교실) ;
  • 김유미 (동아대학교 의과대학 예방의학교실) ;
  • 김록범 (동아대학교 의과대학 예방의학교실) ;
  • 정진용 (동아대학교 중금속노출 환경보건센터) ;
  • 홍영습 (동아대학교 의과대학 예방의학교실)
  • Received : 2014.05.21
  • Accepted : 2014.08.25
  • Published : 2014.08.31

Abstract

Objectives: Children are more susceptible to heavy metal toxicity than adults. The purpose of this study was to evaluate heavy metal concentrations in the blood of Korean preschoolers and investigate the association between metals in blood and related factors. Methods: A total of 512 subjects from 36 to 83 months of age were sampled. A questionnaire survey was performed and the levels of lead, mercury and cadmium were measured in the blood samples of all subjects. Their parents were interviewed in order to obtain information on basic characteristics, dietary patterns, socio-economic factors, and indoor/outdoor environment of the preschoolers. Multiple linear regression was used to analyze the association between the above factors and lead, mercury or cadmium concentrations. Results: The geometric mean concentrations of lead, mercury and cadmium in the blood were $1.45{\pm}1.58{\mu}g/dL$, $2.14{\pm}1.74{\mu}g/dL$ and $0.23{\pm}1.91{\mu}g/dL$, respectively. Results from multiple linear regression analysis showed that blood lead levels were associated with birth weight and paternal smoking status. Daily mercury intake from food and maternal education were also shown to influence mercury concentrations in blood. Also, blood cadmium concentrations were associated with maternal age and having a bus garage near the place of residence. Conclusion: This study suggests that smoking status, dietary patterns and the environmental status near the residence should be considered as important factors for preventable sources of heavy metal exposure in preschoolers.

Acknowledgement

Supported by : 식품의약품안전청

References

  1. Wigle DT, Arbuckle TE, Turner MC, Berube A, Yang Q, Liu S, et al. Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants. J Toxicol Environ Health B Crit Rev. 2008; 11(5-6): 373-517. https://doi.org/10.1080/10937400801921320
  2. Nadal M, Bocio A, Schuhmacher M, Domingo JL. Trends in the levels of metals in soils and vegetation samples collected near a hazardous waste incinerator. Arch Environ Contam Toxicol. 2005; 49: 290-298. https://doi.org/10.1007/s00244-004-0262-2
  3. Wang H, Stuanes AO. Heavy metal pollution in air-water-soil-plant system of Zhuzhou City, Hunan Province, China. Water Air Soil Pollut. 2003; 147: 159-164.
  4. Bellinger D, Leviton A, Allred E, Rabinowitz M. Pre- and postnatal lead exposure and behavior problems in school-aged children. Environ Res. 1994; 66(1): 12-30. https://doi.org/10.1006/enrs.1994.1041
  5. Thatcher RW, Lester ML, McAlaster R, Horst R. Effects of low levels of cadmium and lead on cognitive functioning in children. Arch Environ Health. 1982; 37(3): 159-166. https://doi.org/10.1080/00039896.1982.10667557
  6. Vupputuri S, Longnecker MP, Daniels JI, Guo X, Sandler DP. Blood mercury level and blood pressure among us women: results from the National Health and Nutrition Examination Survey 1999-2000. Environ Res. 2005; 97(2): 195-200. https://doi.org/10.1016/j.envres.2004.05.001
  7. Fassett DW. Metals in the environment. New York: Academic Press; 1980. p.61-100.
  8. Moya J, Bearer CF, Etzel RA. Children's behavior and physiology and how it affects exposure to environmental contaminants. Pediatrics. 2004; 113(4 Suppl) 996-1006.
  9. Wang S, Zhang J. Blood lead levels in children, China. Environ Res. 2006; 101(3): 412-418. https://doi.org/10.1016/j.envres.2005.11.007
  10. Marques RC, Bernardi JV, Dorea JG, de Fatima R Moreira M, Malm O. Perinatal multiple exposure to neurotoxic (lead, methylmercury, ethylmercury, and aluminum) substances and neurodevelopment at six and 24 months of age. Environ Pollut. 2014; 187: 130-135. https://doi.org/10.1016/j.envpol.2014.01.004
  11. Grandjean P, Budtz-Jorgensen E, Steuerwald U, Heinzow B, Needham LL, Jorgensen PJ, et al. Attenuated growth of breast-fed children exposed to increased concentrations of methylmercury and polychlorinated biphenyls. FASEB J. 2003; 17(6): 699-701. https://doi.org/10.1096/fj.02-0661fje
  12. Kippler M, Tofail F, Hamadani JD, Gardner RM, Grantham-McGregor SM, Bottai M, et al. Effects of gestational cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years. Biol Trace Elem Res. 2009; 132(1-3): 51-59. https://doi.org/10.1007/s12011-009-8391-0
  13. Lutz PM, Kelty EA, Brown TD, Wilson TJ, Brock G, Neal RE. Environmental cigarette smoke exposure modulates IgE levels of Pb-exposed children. Toxicology. 2012; 291(1-3): 43-50. https://doi.org/10.1016/j.tox.2011.10.013
  14. Ahamed M, Verma S, Kumar A, Siddiqui MK. Blood lead levels in children of Lucknow, India. Environ Toxicol. 2010; 25(1): 48-54.
  15. Moralez LS, Gutierrez P, Escarce JJ. Demographic and socioeconomic factors associated with blood lead levels among Mexican-American children and adolescents in the United States. Public Health Rep. 2005; 120(4): 448-454. https://doi.org/10.1177/003335490512000412
  16. Lin S, Wang X, Yu IT, Tang W, Miao J, Li J, et al. Environmental lead pollution and elevated blood lead levels among children in a rural area of China. Am J Public Health. 2011; 101(5): 834-841. https://doi.org/10.2105/AJPH.2010.193656
  17. Zheng L, Wu K, Li Y, Qi Z, Han D, Zhang B, et al. Blood lead and cadmium levels and relevant factors among children from an e-waste recycling town in China. Environ Res. 2008; 108(1): 15-20. https://doi.org/10.1016/j.envres.2008.04.002
  18. Myers GJ, Davidson PW, Cox C, Shamlaye CF, Palumbo D, Cernichiari E, et al. Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study. Lancet. 2003; 361(17): 1686-1692. https://doi.org/10.1016/S0140-6736(03)13371-5
  19. Ministry of Food and Drug Safety. A Study on the Integrated Exposure to Hazardous Materials for Safety Control. Osong: Ministry of Food and Drug Safety Press; 2012.
  20. Kim DW, Woo HD, Joo J, Park KS, Oh SY, Kwon HJ, et al. Estimated long-term dietary exposure to lead, cadmium, and mercury in young Korean children. Eur J Clin Nutr. 2014: 1-4. doi: 10.1038/ejcn.2014.116. https://doi.org/10.1038/ejcn.2014.116
  21. Murphy KE, Vetter T, Turk GC, Palmer CD, Lewis Jr ME, Geraghty CM, et al. Comparison of clinical methods with isotope dilution ICP-MS for the new standard reference material 955c lead in caprine blood. J Anal At Spectrom. 2009; 24: 1170-1178. https://doi.org/10.1039/b903060c
  22. Davis WC, Long SE. Measurements of Methylmercury, Ethylmercury, and Inorganic Mercury Species in a whole blood standard reference material: SRM 955c toxic elements in caprine blood. J Anal At Spectrom. 2011; 26: 431-435. https://doi.org/10.1039/c0ja00175a
  23. Murphy KE, Long SE, Vocke RD. On the certification of cadmium at trace and ultra-trace levels in standard reference materials using ID ICP-MS. Anal Bioanal Chem. 2007; 387(7): 2453-2461. https://doi.org/10.1007/s00216-006-0880-9
  24. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables. Washington: U.S. Department of Health & Human Services Press; 2013.
  25. Health Canada. Final human health state of the science report on lead. Available: www.hc-sc.gc.ca/ ewh-semt/pubs/contaminants/dhhssrl-rpecscepsh/indexeng.php[accessed 8 March 2013].
  26. Becker K, MDssig-Zufika M, Conrad A, Schulz C, Seiwert M, Kolossa-Gehring M. Environmental Survey for Children 2003/06 - GerES IV-. Dessau-RoDulau: Umwelt Bundesamt Press; 2008.
  27. Ministry of Environment. National Institute of Environmental Research. Studies on Environmental Exposures and Health Effect in Pregnancy Women and Infants. Sejong: Ministry of Environment Press; 2012.
  28. National Institute of Environmental Research. Korean Environmental Health Survey for Children [VI]. Incheon: National Institute of Environmental Research Press; 2010.
  29. Min KB, Min JY, Cho SI, Kim R, Kim H, Paek D. Relationship between low blood lead levels and growth in children of white-collar civil servants in Korea. Int J Hyg Environ Health. 2008; 211(1-2): 82-87. https://doi.org/10.1016/j.ijheh.2007.03.003
  30. Friedman LS, Lukyanova OM, Kundiev YI, Shkiryak-Nizhnyk ZA, Chislovska NV, Mucha A, et al. Predictors of elevated blood lead levels among 3-year old Ukrainian children: a nested case-control study. Environ Res. 2005; 99(2): 235-242. https://doi.org/10.1016/j.envres.2004.12.006
  31. Liu J, Ai Y, McCauley L, Pinto-Martin J, Yan C, Shen X, et al. Blood lead levels and associated sociodemographic factors among preschool children in the South Eastern region of China. Paediatr Perinat Epidemiol. 2012; 26(1): 61-69. https://doi.org/10.1111/j.1365-3016.2011.01234.x
  32. Garcia-Esquinas E, Perez-Gomez B, Fernandez- Navarro P, Fernandez MA, de Paz C, Perez-Meixeira AM, et al. Lead, mercury and cadmium in umbilical cord blood and its association with parental epidemiological variables and birth factors. BMC Public Health. 2013; 13: 841. https://doi.org/10.1186/1471-2458-13-841
  33. Heo JN, Kim HM, LEE JT. A study of the relationships between proximity to an industrial complex and blood lead levels and urinary cadmium levels. J Environ Health Sci. 2012; 38(2): 95-104.
  34. Ramon R, Ballester F, Aguinagalde X, Amurrio A, Vioque J, Lacasana M, et al. Fish consumption during pregnancy, prenatal mercury exposure, and anthropometric measures at birth in a prospective mother-infant cohort study in Spain. Am J Clin Nutr. 2009; 90(4): 1047-1055. https://doi.org/10.3945/ajcn.2009.27944
  35. Drexler H, Schaller KH. The mercury concentration in breast milk resulting from amalgam fillings and dietary habits. Environ Res. 1998; 77(2): 124-129. https://doi.org/10.1006/enrs.1997.3813
  36. Ho MK, Lim YW, Lim JH, Yang JY, shin DC. Association between blood mercury concentration and factor of health/life. J Environ Toxicol. 2006; 21(3): 229-238.
  37. Grandjean P, White RF, Weihe P, Jorgensen PJ. Neurotoxic risk caused by stable and variable exposure to methylmercury from seafood. Ambul Pediatr. 2003; 3(1): 18-23. https://doi.org/10.1367/1539-4409(2003)003<0018:NRCBSA>2.0.CO;2
  38. Kim HJ, Hong YS, Lee KE, Kim DS, Lee MJ, Yeah BJ, et al. The levels of blood lead and cadmium in urban and rural population in Korea. J Life Sci. 2009; 19(4): 472-478. https://doi.org/10.5352/JLS.2009.19.4.472

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