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Excretion, Tissue Distribution and Toxicities of Titanium Oxide Nanoparticles in Rats after Oral Administration over Five Consecutive Days

티타늄나노입자의 랫드 5일 반복 경구투여 후 배설, 조직분포 및 독성에 관한 평가연구

  • Kim, Hyejin (College of Pharmacy, Dongduk Women's University) ;
  • Park, Kwangsik (College of Pharmacy, Dongduk Women's University)
  • 김혜진 (동덕여자대학교 약학대학) ;
  • 박광식 (동덕여자대학교 약학대학)
  • Received : 2014.07.09
  • Accepted : 2014.08.28
  • Published : 2014.08.31

Abstract

Objectives: Excretion and tissue distribution of titanium oxide nanoparticles were evaluated in rats after oral administration. The relation between toxicity and systemic concentration of nanoparaticles was investigated. Methods: Rats were orally treated with titanium oxide nanoparticles (10, 100 mg/kg) for five consecutive days. General toxicity, blood chemistry, and serum biochemical analysis were analyzed. Titanium concentration in liver, kidney, lung, urine and feces were measured and histopathology was performed in these organs. Results: Induction of toxicological parameters was not observed and titanium nanoparticles were excreted via feces. Conclusion: Absorption of titanium oxide nanoparticles via the gastrointestinal tract after oral administration was very poor and systemic concentration of titanium oxide nanoparticles was not elevated. Titanium oxide nanoparticles did not cause toxicities in rats after oral administration.

Acknowledgement

Supported by : 동덕여자대학교

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