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Resveratrol Prevents Hormone-refractory Prostate Cancer Cell Growth via Inhibition of STAT3 Activity

STAT3 활성 억제를 유도하는 resveratrol의 호르몬 불응성 전립선 암 예방 효과

  • Cho, Seok-Cheol (Department of Food Science and Engineering, Seowon University) ;
  • Choi, Bu Young (Department of Pharmaceutical Science and Engineering, Seowon University)
  • 조석철 (서원대학교 바이오융합학부 식품공학과) ;
  • 최부영 (서원대학교 바이오융합학부 제약공학과)
  • Received : 2014.05.29
  • Accepted : 2014.07.07
  • Published : 2014.08.31

Abstract

The mechanisms underlying the refractory effects of flutamide, a first-line oral anti-androgen drug, have not been entirely elucidated. In the present study, we investigated the mechanism of flutamide-induced hormone-refractory prostate cancer cell growth and its modulation by resveratrol, a phytoalexin present in grapes. Resveratrol significantly attenuated interleukin 6 (IL-6)-induced signal transducer and activator of transcription 3 (STAT3) transcriptional activity and dihydrotestosterone (DHT) or IL-6-induced prostate-specific antigen (PSA) transcriptional activity. Furthermore, compared to treatment with DHT or IL-6 alone, combination treatment of cells significantly increased PSA transcriptional activity, and resveratrol markedly diminished DHT plus IL-6-induced STAT3 and PSA transcriptional activities. Thus, the inhibitory effects of resveratrol on IL-6-, DHT-, and flutamide-induced hormone-refractory prostate cancer cell growth are partly mediated by the suppression of STAT3 reporter gene activity, suggesting that resveratrol represents a promising therapy for prostate cancer.

Keywords

resveratrol;STAT3;IL-6;DHT;hormone-refractory prostate cancer

Acknowledgement

Supported by : 한국산업단지공단

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