- Volume 17 Issue 3
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Plexiform Neurofibroma Treated with Pharmacopuncture
- Lim, Chungsan (Department of Oriental Medicine, Seil Hospital) ;
- Kwon, Kirok (Ginseng & Venom, Sangji University College of Korean Medicine) ;
- Lee, Kwangho (Department of Acupuncture & Moxibustion Medicine, Sangji University College of Korean Medicine)
- Received : 2014.06.09
- Accepted : 2014.07.07
- Published : 2014.09.30
Objectives: The purpose of this study is to report a case of a plexiform neurofibroma (PNF) in the pelvic region treated with sweet bee venom (SBV) and mountain ginseng pharmacopuncture (MGP). Methods: A 16-year-old girl was diagnosed as having PNFs, neurofibromatosis type 1, 10 years ago and she had surgery three times to remove the benign tumors, but the growth of the PNFs continued. She has been treated in our clinic with SBV and MGP two times per month from March 2010 to April 2014. SBV was injected intra-subcutaneously at the borders of the PNFs in the pelvic region, and MGP was administrated intravenously each treatment time. Results: The growths of the PNFs occurred rapidly and continued steadily before treatment. Since March 2010, she has been treated in our clinic, and the growths of the PNFs have almost stopped; further-more, the discomfort of hip joint pain has been reduced, and her general condition has improved. Conclusion: We cautiously conclude that SBV and MGP treatment has some effects that suppress the growth and the spread of the PNFs in this patient.
Supported by : Sangji University
- Samii M, Gerganov VM. Neurofibromatosis neurosurgical treatment and follow up. Eur Neurol Rev. 2007;(2):14-6.
- Neurofibromatosis. conference statement. national institutes of health consensus development conference. Arch Neurol 1988;45(5):575-8. https://doi.org/10.1001/archneur.1988.00520290115023
- Tonsgard JH. Clinical manifestations and management of neurofibromatosis type 1. Semin Pediatr Neurol. 2006;13(1):2-7. https://doi.org/10.1016/j.spen.2006.01.005
- Korf BR. Plexiform neurofibromas. Am J Med Genet. 1999;89(1):31-7. https://doi.org/10.1002/(SICI)1096-8628(19990326)89:1<31::AID-AJMG7>3.0.CO;2-W
- Woodruff JM. Pathology of tumors of the peripheral nerve sheath in type 1 neurofibromatosis. Am J Med Genet. 1999;89(1):23-30. https://doi.org/10.1002/(SICI)1096-8628(19990326)89:1<23::AID-AJMG6>3.0.CO;2-#
- Momoh JT. Plexiform neurofibroma in children. East Afr Med J. 1986;63(5):334-8.
- Donner TR, Voorhies RM, Kline DG. Neural sheath tumors of major nerves. J Neurosurg. 1994 ;81(3):362-73. https://doi.org/10.3171/jns.1994.81.3.0362
- Friedrich RE, Schmelzle R, Hartmann M, Fünsterer C, Mautner VF. Resection of small plexiform neurofibromas in neurofibromatosis type 1 children. World J Surg Oncol. 2005;3(1):6. https://doi.org/10.1186/1477-7819-3-6
- Cebesoy O, Tutar E, Isik M, Arpacioglu O. A case of isolated giant plexiform neurofibroma involving all branches of the common peroneal nerve. Arch Orthop Trauma Surg. 2007;127(8):709-12. https://doi.org/10.1007/s00402-007-0303-1
- Sehgal VN, Srivastava G, Aggarwal AK, Oberai R. Plexiform neurofibromas in neurofibromatosis type 1. Int J Dermatol. 2009;48(9):971-4. https://doi.org/10.1111/j.1365-4632.2008.04041.x
- Sehgal VN, Sharma S, Oberai R. Evaluation of plexiform neurofibroma in neurofibromatosis type 1 in 18 family members of 3 generations: ultrasonography and magnetic resonance imaging a diagnostic supplement. Int J Dermatol. 2009;48(3):275-9. https://doi.org/10.1111/j.1365-4632.2009.03999.x
- Hope DG, Mulvihill JJ. Malignancy in neurofibromatosis. Adv Neurol. 1981;29:33-56.
- Korean Pharmacopuncture Institute. Pharmacopuncturology:principles and clinical applications. Seoul:Elsevier Korea LLC; Chapter 09, Animal based pharmacopuncture. 2012; p. 147-79.
- Dugoff L, Sujansky E. Neurofibromatosis type 1 and pregnancy. Am J Med Genet. 1996;66(1):7-10. https://doi.org/10.1002/(SICI)1096-8628(19961202)66:1<7::AID-AJMG2>3.0.CO;2-R