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Analysis of the effects of δ-Aminolevulinic acid on the proliferation and apoptosis of mammalian cells

포유류 세포주에서 δ-Aminolevulinic acid (ALA)의 세포증식과 사멸에 미치는 영향분석

  • Jun, Yong-Woo (Department of Ecological Science, College of Ecology and Environment, Kyungpook National University) ;
  • Kim, Kun-Hyung (Department of Ecological Science, College of Ecology and Environment, Kyungpook National University) ;
  • Jo, Su-Yeon (WEDEA Co.) ;
  • Lee, Jin-A (Department of Biotechnology, College of Life Science and Nano Technology, Hannam University) ;
  • Jang, Deok-Jin (Department of Ecological Science, College of Ecology and Environment, Kyungpook National University)
  • 전용우 (경북대학교 생태환경대학 생태과학과) ;
  • 김건형 (경북대학교 생태환경대학 생태과학과) ;
  • 조수연 ((주)위디어) ;
  • 이진아 (한남대학교 생명나노과학대학 시스템생명과학과) ;
  • 장덕진 (경북대학교 생태환경대학 생태과학과)
  • Received : 2014.06.07
  • Accepted : 2014.08.06
  • Published : 2014.10.25

Abstract

${\delta}$-Aminolevulinic acid (ALA) is a compound which is widely present in the biosphere and plays an important role in the living body as an intermediate of the tetrapyrrole compound biosynthesis pathway that leads to heme in mammals and chlorophyll in plants. ALA is of interest as a biodegradable mediator, a growth regulator, a precursor of heme proteins, and an effective agent used in therapy of cancer. It has been recently reported that ALA is commonly used in dermatology, due to good effects of skin therapy. Although for the last few decades a substantial amount of research has been focused on the elucidation of the mechanism of ALA and the improvement of its therapeutic activity, it's effect on the cell functions and growth was not cleared. Here, we identified that ALA treatment could attenuate cell proliferation of HEK293T and HaCaT cells. In addition, ALA treatement could induce apoptosis of HeLa cells. These results suggest that apoptosis induced by ALA treatment might be responsible for inhibition of cell proliferation. These results propose the possibility of the improved therapeutic strategy making ALA one of the effective drugs used in human cancers.

Keywords

${\delta}$-Aminolevulinic acid;Apoptosis;cell proliferation;cell growth

Acknowledgement

Supported by : 한국산업기술진흥원

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Cited by

  1. Inhibition of Proliferation of Human Fibroblast by δ-Aminolevulinic Acid (ALA) Derivatives through the Induction of Mitochondria Membrane Depolarization vol.30, pp.6, 2015, https://doi.org/10.7841/ksbbj.2015.30.6.313