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Fabrication and characterization of block copolymer (PCL/PCL-PEG) nanofibers binding with collagen by electrospun

콜라겐 코팅된 블록공중합(PCL/PCL-PEG) 나노섬유의 제조 및 특성분석

  • Lee, Jin Woo (Department of Chemistry, College of life Science and Nano Technology, Hannam University) ;
  • Yoon, Kuk Ro (Department of Chemistry, College of life Science and Nano Technology, Hannam University)
  • 이진우 (한남대학교 생명나노과학대학 화학과) ;
  • 윤국로 (한남대학교 생명나노과학대학 화학과)
  • Received : 2014.08.27
  • Accepted : 2014.09.30
  • Published : 2014.10.25

Abstract

Electrospun polymeric nanofibers have been extensively studied for biomedical materials because of their unique structures and relatively easy fabrication with biocompatible polymers. The amount of surface exposed amine groups increases as the blend ratio of block copolymer increases. Cell attachments on the nanofibers change according to the ratio of the block copolymer ((Poly(e-caprolactone, PCL), Poly(e-caprolactone)-Poly (ethylen glycol-$NH_2$)) in the blend. We assume that the PEG and amine moiety plays a significant role in biocompatibility of nanofiber surfaces. Collagen was used as a grafting material on the composite nanofibers to enhance the cell adhesion because the collagen is a major constituent of connective tissue.

Keywords

Block copolymer (PCL/PCL-PEG);Nanofiber;collagen;biocompatibility;cell adhesion

Acknowledgement

Supported by : Hannam University

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