심재성 2도 화상이 유발된 흰쥐의 조직 회복에 대한 침 및 한약외용제의 효과

Therapeutic Effects of Acupuncture and Herbal External Preparation on Healing of Deep Partial Thickness Burn Wound in Rats

  • 조희근 (순창의료원) ;
  • 박애련 (동신대학교 한의과대학 한방재활의학과교실) ;
  • 최진봉 (동신대학교 한의과대학 한방재활의학과교실)
  • Jo, Hee-Guen (Sunchng Health Center and County Hospital) ;
  • Park, Ae-Ryon (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dong-Shin University) ;
  • Choi, Jin-Bong (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dong-Shin University)
  • 투고 : 2014.06.18
  • 심사 : 2014.07.14
  • 발행 : 2014.07.31


Objectives The present study aimed to investigate the effects of acupuncture and herbal external preparation on wound healing procedure in a deep partial thickness burn model in rats. Methods A total of 40 male Sprague-Dawley rats were allocated into four groups with an equal number in each group: acupuncture treatment group, herbal external perparation group, Silver sulfadiazine dressing group and control group. We describe the effect of acupuncture and herbal external preparation on morphologic and histologic changes, epithelial growth factor (EGF), hematological value of the deep partial thickness burn wound in rats. Results At 21th day after wounding the wound size in acupuncture treat group and herbal external preparation group were decreased more significantly compared to control group. In addition, epidermal regeneration on acupuncture treatment was than other treatment and control group in histological finding. Hematological findings revealed that acupuncture treatment group and herbal external prepartion group was more effective than control group in reducing inflammation response induced by burn. In acupuncture treated group, neutrophil and leukocyte level were significantly decreased compared to other treatment group. Also, this study showed that EGF was obviously expressed in nascent tissue when wounds were treated with the acupuncture and herbal external preparation after injury. In particular, acupuncture treatment group had a significant increase of EGF expression in burn wound healing area when compared with the other treatment groups. Conclusions These findings suggest that acupuncture and herbal external prepration may improve burn wound healing through decreasing inflammatory reaction, increasing tissue regeneration and expression of EGF. Moreover, acupuncture treatment could be more effective in comparison with Silver sulfadiazine dressing.


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