Progression of NETs Correlating with Tumor-Related Diseases

  • Zhang, Le-Meng (Thoracic Medicine Department 1, Hunan Cancer Hospital, Affiliated to Xiangya Medical School, Central South University) ;
  • Chen, Jian-Hua (Thoracic Medicine Department 1, Hunan Cancer Hospital, Affiliated to Xiangya Medical School, Central South University)
  • Published : 2015.12.03


As an important component of innate immune system, neutrophil has been involved in many other physiological processes, including tumor-related diseases. In 2004, the phenomenon of NETs was reported for the first time. Extracellular decondensed chromatin, released from activated neutrophils, forms a network structure, which is NETs. This review focuses on the function of NETs in tumor cell proliferation, metastasis, and tumor-associated thrombosis; it also explores the application of NETs specific markers in the diagnosis of pre-thrombotic state and tumor associated diseases; it also explores NETs inhibitor for the treatment of tumor-related diseases. In view of the rapid development of NETs, it may provide new therapeutic targets for tumor-associated thrombosis, and even tumor itself.


Neutrophil extracellular traps;tumor-related diseases;thrombosis;citrullinated histone


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