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Can Cancer Therapy be Achieved by Bridging Apoptosis and Autophagy: a Method Based on microRNA-Dependent Gene Therapy and Phytochemical Targets

  • Vijayarathna, Soundararajan (Institute for Research in Molecular Medicine, Universiti Sains Malaysia) ;
  • Gothai, Sivapragasam (Institute for Research in Molecular Medicine, Universiti Sains Malaysia) ;
  • Jothy, Subramanion L (Institute for Research in Molecular Medicine, Universiti Sains Malaysia) ;
  • Chen, Yeng (Dental Research & Training Unit, and Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, University of Malaya) ;
  • Kanwar, Jagat R (Nanomedicine Laboratory of Immunology and Molecular Biomedical Research, School of Medicine, Faculty of Health, Institute for Frontier Materials, Deakin University) ;
  • Sasidharan, Sreenivasan (Institute for Research in Molecular Medicine, Universiti Sains Malaysia)
  • Published : 2015.12.03

Abstract

A failure of a cell to self destruct has long been associated with cancer progression and development. The fact that tumour cells may not instigate cell arrest or activate cell death mechanisms upon cancer drug delivery is a major concern. Autophagy is a mechanism whereby cell material can be engulfed and digested while apoptosis is a self-killing mechanism, both capable of hindering multiplication after cell injury. In particular situations, autophagy and apoptosis seem to co-exist simultaneously or interdependently with the aid of mutual proteins. This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage.

Keywords

Autophagy;apoptosis;microRNAs;natural remedies

Acknowledgement

Supported by : Ministry of Education Malaysia, University of Malaya

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