- Volume 16 Issue 17
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Lifestyle and Sporadic Colorectal Cancer in India
- Sinha, Rupal (Department of Research, Rajiv Gandhi Cancer Institute & Research Centre) ;
- Doval, Dinesh Chandra (Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre) ;
- Hussain, Showket (Division of Molecular Genetics & Biochemistry, Institute of Cytology & Preventive Oncology (ICMR)) ;
- Kumar, Kapil (Department of Surgical Oncology, Rajiv Gandhi Cancer Institute & Research Centre) ;
- Singh, Shivendra (Department of Surgical Oncology, Rajiv Gandhi Cancer Institute & Research Centre) ;
- Basir, Seemi Farhat (Department of Biosciences, Jamia Millia Islamia) ;
- Bharadwaj, Mausumi (Division of Molecular Genetics & Biochemistry, Institute of Cytology & Preventive Oncology (ICMR))
- Published : 2015.12.03
Background: The study evaluated the patient, lifestyle and tumor profile in patients undergoing upfront surgery for sporadic colorectal cancer (CRC) in Indian population. Materials and Methods: One hundred consecutive patients were included. Details related to their demographic profile, habits, signs and symptoms, tumor profile, further treatment and follow up were recorded. Results: The majority of the patients had colonic cancer (68%), advanced tumor stage 3 & 4 (46%), moderately differentiated tumors (70%) with absence of lymphatic invasion (60%) and metastasis (90%). Correlations between tumor location and abdominal pain (p-value 0.002), bleeding per rectum (p-value <0.001), difficulty in micturition (p-value 0.012) and constipation (p-value 0.007) were found to be statistically significant. Abdominal pain was more frequently reported in patients with metastasis (p-value 0.031). Loss of weight statistically correlated with absence of lymphatic invasion (p-value 0.047). Associations between tumor stage and alcohol intake (p-value 0.050) and non vegetarian diet (p-value 0.006); lymphatic invasion and intake of spicy food (p-value 0.040) and non vegetarian diet (p-value 0.001) and metastasis and alcohol intake (p-value 0.041) were also observed. Age and tumor grade were also correlated (p-value 0.020). Conclusions: Minimizing the adverse lifestyle factors can help in reducing the overall incidence of CRC in the Indian population.
Signs and symptoms;tumor profile;lifestyle factors;sporadic colorectal cancer
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