Asian Pacific Journal of Cancer Prevention
- Volume 16 Issue 17
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- Pages.7701-7705
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- 2015
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- 1513-7368(pISSN)
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- 1513-7368(eISSN)
DOI QR Code
Alteration of Thyroid Function in Indian HER 2-Negative Breast Cancer Patients Undergoing Chemotherapy
- Ashif Khan, Mohd (Department of Pharmaceutical Medicine, Faculty of Pharmacy, Jamia Hamdard (Hamdard University)) ;
- Bhurani, Dinesh (Hemato-Oncology Services & Senior Bone Marrow Transplant Specialist, Rajiv Gandhi Cancer Institute & Research Centre) ;
- Agarwal, Nidhi B (Centre for Translational & Clinical Research, Faculty of Science, Jamia Hamdard (Hamdard University))
- Published : 2015.12.03
Abstract
Background: Thyroid hormones (TH) are regulated by the hypothalamic-pituitary axis, which plays an important role in cell growth, differentiation, development and other aspects of metabolism. It is believed that an active hypothalamic-pituitary axis increases the susceptibility of thyroid dysfunction during systemic chemotherapy. In order to investigate the relation between thyroid function and chemotherapy the present study was designed to investigate TH in breast cancer patients receiving at least three cycles of chemotherapy. The levels of TH were measured at the baseline and before each cycle of chemotherapy. Materials and Methods: Blood samples for estimation of TH levels were collected from 80 (pre-menopausal-40; post-menopausal-40) breast cancer patients just before they were undergoing -
Keywords
Thyroid hormone;chemotherapy;breast cancer;subclinical hypothyroidism;menopause
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